SCHEMBL7740084

SCHEMBL7740084

COc1cccc(Oc2c[c]c(F)cc2Cl)c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.42
NPSR1 Q6W5P4 3/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
KDM4E B2RXH2 2/20 0.41
POLB P06746 1/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
EGFR P00533 1/20 0.38
ERBB2 P04626 1/20 0.38
ERBB3 P21860 1/20 0.38
ERBB4 Q15303 1/20 0.38
LMNA P02545 2/20 0.37
ALDH1A1 P00352 2/20 0.37
HTT P42858 1/20 0.37
RAB9A P51151 1/20 0.37
MAOB P27338 2/20 0.37
MEN1 O00255 3/20 0.36
KMT2A Q03164 3/20 0.36
HPGD P15428 1/20 0.36
ACHE P22303 1/20 0.36
USP2 O75604 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7740050 0.86 RAB9A (0.38) MAPTL3MBTL1POLBSMN1; SMN2LMNA
SCHEMBL7740258 0.82 STK39 (0.44) RAB9ATSHR
SCHEMBL7745408 0.79 AR (0.49) MAPTNPSR1L3MBTL1KDM4EPOLB
SCHEMBL7740056 0.79 L3MBTL1 (0.42) MAPTL3MBTL1SMN1; SMN2ALDH1A1HTT
SCHEMBL7740123 0.79 MAOB (0.38) LMNAMAOBMEN1KMT2A
SCHEMBL718547 0.77 NPC1 (0.41) MAPTNPSR1L3MBTL1KDM4EPOLB
SCHEMBL7747650 0.76 PPARA (0.45) MAPTNPSR1KDM4EPOLBSMN1; SMN2
SCHEMBL7740190 0.74 MEN1 (0.41) MEN1KMT2AMAPK1
SCHEMBL16068865 0.73 KDM4E (0.44) MAPTNPSR1L3MBTL1KDM4EPOLB
SCHEMBL919676 0.73 SMN1; SMN2 (0.50) MAPTNPSR1L3MBTL1KDM4EPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2001009087-A1 SUBSTITUTED ARYLHYDRAZONE CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS HERBICIDES BAYER AKTIENGESELLSCHAFT (DE) 2001-02-08 WO disclosed