SCHEMBL7740258

SCHEMBL7740258

Oc1cccc(Oc2c[c]c(F)cc2Cl)c1

nearest known ligand 0.44

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
STK39 Q9UEW8 2/20 0.44
RAB9A P51151 1/20 0.42
MRGPRX4 Q96LA9 1/20 0.37
ESR1 P03372 1/20 0.35
ESR2 Q92731 1/20 0.35
HSP90AA1 P07900 1/20 0.35
CYP3A4 P08684 1/20 0.35
TSHR P16473 1/20 0.34
F10 P00742 1/20 0.34
RET P07949 1/20 0.33
KIF5B P33176 1/20 0.33
KDR P35968 1/20 0.33
THRA P10827 1/20 0.33
THRB P10828 1/20 0.33
ESRRA P11474 1/20 0.33
F2 P00734 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7740190 0.83 MEN1 (0.41) STK39ESR1ESR2HSP90AA1F10
SCHEMBL7740084 0.82 MAPT (0.42) RAB9ATSHR
SCHEMBL7745251 0.79 AR (0.40)
SCHEMBL7740123 0.76 MAOB (0.38)
SCHEMBL7744203 0.76 STK39 (0.41) STK39HSP90AA1TSHR
SCHEMBL7740050 0.74 RAB9A (0.38) RAB9A
SCHEMBL7747650 0.73 PPARA (0.45) CYP3A4F10
SCHEMBL9826918 0.73 MRGPRX4 (0.63) STK39MRGPRX4HSP90AA1CYP3A4TSHR
SCHEMBL10775157 0.73 CAMK2A (0.48) STK39RAB9AMRGPRX4HSP90AA1CYP3A4
SCHEMBL18708752 0.71 ACHE (0.46) STK39RAB9AMRGPRX4HSP90AA1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2001009087-A1 SUBSTITUTED ARYLHYDRAZONE CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS HERBICIDES BAYER AKTIENGESELLSCHAFT (DE) 2001-02-08 WO disclosed