Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 2/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | CCKBR | P32239 | 1/20 | 0.35 |
| ▸ | GLS | O94925 | 1/20 | 0.35 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.35 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7740469 | 0.85 | HDAC6 (0.34) | NAMPTCCKBRGLSHDAC10HDAC6 | |
| SCHEMBL7740422 | 0.83 | SYK (0.40) | MEN1ALDH1A1MAPTKMT2ALMNA | |
| SCHEMBL7734198 | 0.82 | TSHR (0.34) | MEN1ALDH1A1MAPTKMT2ALMNA | |
| SCHEMBL7740426 | 0.81 | PDK1 (0.40) | NAMPTSYKPDK1PDK2PDK3 | |
| SCHEMBL7740478 | 0.81 | SYK (0.37) | MEN1ALDH1A1MAPTKMT2ALMNA | |
| SCHEMBL7739655 | 0.80 | KMT2A (0.36) | MEN1ALDH1A1MAPTKMT2ALMNA | |
| SCHEMBL7740427 | 0.80 | NOS1 (0.38) | SYK | |
| SCHEMBL27525664 | 0.80 | RXFP1 (0.35) | MEN1ALDH1A1MAPTKMT2ALMNA | |
| SCHEMBL27564542 | 0.79 | JAK2 (0.39) | KMT2ANAMPTGLS | |
| SCHEMBL27577235 | 0.79 | IDO1 (0.43) | MEN1ALDH1A1KMT2ALMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1217928-C | Heterocyclic compound having NOS inhibitory action | CHUGAI SEIYAKA K K (JP) | 2005-09-07 | — | — | CN | disclosed |
| US-6414005-B1 | BRAIN DISORDERS; ALZHEIMER'S DISEASE; PARKINSON'S DISEASE | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2002-07-02 | — | — | US | disclosed |
| CN-1280565-A | Heterocyclic compounds having NOS inhibitory activities | CHUGAI SEIYAKA K K (JP) | 2001-01-17 | — | — | CN | disclosed |
| EP-1043312-A1 | HETEROCYCLIC COMPOUNDS HAVING NOS INHIBITORY ACTIVITIES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2000-10-11 | — | — | EP | disclosed |