Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.46 |
| ▸ | DRD1 known ✓ | P21728 | 1/20 | 0.46 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.46 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.46 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.46 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.46 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.46 |
| ▸ | HRH3 known ✓ | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.47 |
| ▸ | LSS | P48449 | 2/20 | 0.47 |
| ▸ | PRMT1 | Q99873 | 3/20 | 0.46 |
| ▸ | F2 | P00734 | 2/20 | 0.46 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.46 |
| ▸ | PLAU | P00749 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.46 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL6407424 | 0.93 | MMP1 (0.53) | CYP2D6TP53TSHR | |
| SCHEMBL548439 | 0.87 | PRSS1 (0.60) | L3MBTL1PRSS1PRMT1F2ST14 | |
| Pentamidine Dao SCHEMBL548448 | 0.85 | PRMT1 (0.61) | L3MBTL1PRSS1PRMT1F2ST14 | |
| SCHEMBL549185 | 0.84 | TMPRSS2 (0.60) | L3MBTL1PRSS1PRMT1F2ST14 | |
| SCHEMBL8718224 | 0.80 | TP53 (0.57) | PRSS1GAATP53TSHR | |
| SCHEMBL1285064 | 0.79 | PPARA (0.51) | — | |
| SCHEMBL20332718 | 0.79 | TMPRSS2 (0.55) | PRSS1PRMT1F2ST14PLAU | |
| SCHEMBL6407420 | 0.79 | MMP1 (0.56) | PRSS1GAATMPRSS2CYP2D6TP53 | |
| SCHEMBL6510086 | 0.78 | TP53 (0.59) | PRMT1F2ST14PLAUGAA | |
| SCHEMBL5543953 | 0.78 | PRMT1 (0.53) | ALDH1A1PRSS1PRMT1F2ST14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6423737-B2 | Benzamidoxime prodrugs as antipneumocystic agents | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | 2002-07-23 | — | — | US | disclosed |