Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7744716 | 0.90 | HSD17B10 (0.45) | KDM4EHSD17B10MAPK1FYNL3MBTL1 | |
| SCHEMBL1899260 | 0.81 | ALDH1A1 (0.54) | KDM4EHSD17B10MAPK1L3MBTL1ALDH1A1 | |
| SCHEMBL3064335 | 0.80 | L3MBTL1 (0.56) | KDM4EHSD17B10MAPK1L3MBTL1ALDH1A1 | |
| SCHEMBL1848071 | 0.75 | CYP19A1 (0.59) | KDM4EMAPK1ALDH1A1PKMMEN1 | |
| SCHEMBL30620657 | 0.75 | CYP19A1 (0.59) | KDM4EMAPK1ALDH1A1PKMMEN1 | |
| SCHEMBL595201 | 0.71 | ALDH1A1 (0.57) | KDM4EHSD17B10MAPK1L3MBTL1ALDH1A1 | |
| SCHEMBL3074455 | 0.70 | NPC1 (0.59) | KDM4EHSD17B10MAPK1L3MBTL1ALDH1A1 | |
| SCHEMBL10022668 | 0.69 | CYP19A1 (0.62) | KDM4EMAPK1ALDH1A1PKMMEN1 | |
| SCHEMBL27768542 | 0.68 | CYP19A1 (0.63) | KDM4EMAPK1ALDH1A1PKMNPC1 | |
| SCHEMBL17593153 | 0.67 | SMN1; SMN2 (0.56) | L3MBTL1ALDH1A1POLBRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1252156-A1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | University College London (GB) | 2002-10-30 | — | — | EP | disclosed |
| WO-2001057024-A1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | UNIVERSITY COLLEGE LONDON (GB) | 2001-08-09 | — | — | WO | disclosed |