Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7744714 | 0.90 | KDM4E (0.43) | HSD17B10KDM4EMAPK1NPC1CYP3A4 | |
| SCHEMBL1899260 | 0.83 | ALDH1A1 (0.54) | HSD17B10KDM4EMAPK1NPC1ALDH1A1 | |
| SCHEMBL3064335 | 0.82 | L3MBTL1 (0.56) | HSD17B10KDM4EMAPK1ALDH1A1GAA | |
| SCHEMBL595201 | 0.73 | ALDH1A1 (0.57) | HSD17B10KDM4EMAPK1ALDH1A1GAA | |
| SCHEMBL30098510 | 0.71 | CYP19A1 (0.69) | KDM4EMAPK1NPC1CYP3A4ALDH1A1 | |
| SCHEMBL128811 | 0.71 | CYP19A1 (0.69) | KDM4EMAPK1NPC1CYP3A4ALDH1A1 | |
| Bromide SCHEMBL15689048 | 0.69 | CYP19A1 (0.67) | KDM4EMAPK1NPC1CYP3A4ALDH1A1 | |
| SCHEMBL17593153 | 0.68 | SMN1; SMN2 (0.56) | ALDH1A1L3MBTL1POLBRAB9ASMN1; SMN2 | |
| SCHEMBL1898402 | 0.66 | SMN1; SMN2 (0.52) | KDM4ENPC1CYP2C9CYP1A2CYP2C19 | |
| SCHEMBL12601966 | 0.65 | ADORA1 (0.44) | HSD17B10KDM4ENPC1CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1252156-A1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | University College London (GB) | 2002-10-30 | — | — | EP | disclosed |
| WO-2001057024-A1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | UNIVERSITY COLLEGE LONDON (GB) | 2001-08-09 | — | — | WO | disclosed |