Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | PKM | P14618 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 6/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7744716 | 0.83 | HSD17B10 (0.45) | ALDH1A1PKMPOLBMAPTKDM4E | |
| SCHEMBL1898414 | 0.75 | MAPT (0.50) | ALDH1A1MAPTKDM4ESMN1; SMN2RAB9A | |
| SCHEMBL1900139 | 0.74 | POLB (0.53) | ALDH1A1POLBMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL1896105 | 0.73 | MAPT (0.56) | ALDH1A1PKMMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL3064335 | 0.73 | L3MBTL1 (0.56) | ALDH1A1KDM4ESMN1; SMN2TDP1KMT2A | |
| SCHEMBL25287793 | 0.72 | LMNA (0.90) | ALDH1A1PKMMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL10697632 | 0.71 | ALDH1A1 (0.76) | ALDH1A1PKMPOLBMAPTKDM4E | |
| SCHEMBL18997302 | 0.70 | ALDH1A1 (0.72) | ALDH1A1PKMMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL1898402 | 0.69 | SMN1; SMN2 (0.52) | ALDH1A1MAPTKDM4ESMN1; SMN2LMNA | |
| SCHEMBL1899880 | 0.69 | NPC1 (0.55) | ALDH1A1PKMPOLBMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1252156-B1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | UCL BUSINESS PLC (GB) | 2011-05-04 | — | — | EP | disclosed |
| EP-1252156-A1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | University College London (GB) | 2002-10-30 | — | — | EP | disclosed |
| WO-2001057024-A1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | UNIVERSITY COLLEGE LONDON (GB) | 2001-08-09 | — | — | WO | disclosed |