Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CXCL8 | P10145 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KCNA5 | P22460 | 4/20 | 0.38 |
| ▸ | KCNN4 | O15554 | 3/20 | 0.38 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.37 |
| ▸ | GRM8 | O00222 | 1/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.37 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CFD | P00746 | 1/20 | 0.36 |
| ▸ | F11 | P03951 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8057254 | 0.87 | CXCL8 (0.40) | LMNASMN1; SMN2L3MBTL1CXCL8SLC6A2 | |
| SCHEMBL8046805 | 0.79 | ITGB3 (0.43) | LMNASMN1; SMN2L3MBTL1TBXAS1KCNA5 | |
| SCHEMBL7744762 | 0.79 | CXCL8 (0.40) | L3MBTL1CXCL8CFDF11TPSB2 | |
| SCHEMBL7746878 | 0.79 | CXCL8 (0.40) | SMN1; SMN2CXCL8SLC6A2SLC6A4CFD | |
| SCHEMBL5060069 | 0.76 | GRM8 (0.43) | LMNASMN1; SMN2L3MBTL1SLC6A2SLC6A4 | |
| SCHEMBL7744718 | 0.75 | TDP1 (0.47) | L3MBTL1CXCL8KDM4E | |
| SCHEMBL8058590 | 0.74 | NAPRT (0.51) | CXCL8TBXAS1NAPRTSGMS2 | |
| SCHEMBL5057897 | 0.72 | TBXAS1 (0.44) | LMNASMN1; SMN2L3MBTL1PDE4DTBXAS1 | |
| SCHEMBL8057233 | 0.71 | PPARG (0.41) | SMN1; SMN2CXCL8SLC6A2SLC6A4CFD | |
| SCHEMBL7744350 | 0.71 | CXCL8 (0.45) | L3MBTL1CXCL8CFDF11TPSB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6046180-A | NAALADase inhibitors | GUILFORD PHARMACEUTICALS INC. (US) | 2000-04-04 | — | — | US | disclosed |