Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCL8 | P10145 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CFD | P00746 | 4/20 | 0.34 |
| ▸ | F11 | P03951 | 4/20 | 0.34 |
| ▸ | TPSB2 | P20231 | 4/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CAMK2A | Q9UQM7 | 2/20 | 0.33 |
| ▸ | FABP4 | P15090 | 1/20 | 0.33 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | PLG | P00747 | 1/20 | 0.31 |
| ▸ | PLAU | P00749 | 1/20 | 0.31 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.31 |
| ▸ | F7 | P08709 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8063985 | 0.86 | CXCL8 (0.41) | CXCL8TDP1L3MBTL1CFDF11 | |
| SCHEMBL7746878 | 0.80 | CXCL8 (0.40) | CXCL8TDP1CFDF11TPSB2 | |
| SCHEMBL8064207 | 0.79 | LMNA (0.40) | CXCL8L3MBTL1CFDF11TPSB2 | |
| SCHEMBL8057208 | 0.79 | PTGS2 (0.39) | CXCL8CAMK2A | |
| SCHEMBL7744718 | 0.76 | TDP1 (0.47) | CXCL8TDP1L3MBTL1ALDH1A1 | |
| SCHEMBL5051182 | 0.74 | IDO1 (0.36) | — | |
| SCHEMBL8059158 | 0.73 | CXCL8 (0.44) | CXCL8TDP1L3MBTL1CFDF11 | |
| SCHEMBL8057233 | 0.72 | PPARG (0.41) | CXCL8CFDF11TPSB2CHRM1 | |
| SCHEMBL5053144 | 0.71 | FOLH1 (0.34) | — | |
| SCHEMBL18607331 | 0.70 | CXCL8 (0.58) | CXCL8TDP1L3MBTL1CFDF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002514160-A | — | — | 2002-05-14 | — | — | JP | claimed |
| EP-0936914-A1 | HYDROXY-PHOSPHINYL DERIVATIVES USEFUL AS NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1999-08-25 | — | — | EP | claimed |
| EP-0936914-A4 | — | — | 1999-08-25 | — | — | EP | claimed |
| WO-1997048400-A1 | HYDROXY-PHOSPHINYL DERIVATIVES USEFUL AS NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1997-12-24 | — | — | WO | claimed |
| US-6046180-A | NAALADase inhibitors | GUILFORD PHARMACEUTICALS INC. (US) | 2000-04-04 | — | — | US | disclosed |