Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES2 | Q9H7Z7 | 3/20 | 0.47 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.42 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 3/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16156847 | 0.75 | FABP4 (0.54) | PTGES2KDM4EGAAPTGESUSP2 | |
| SCHEMBL8687445 | 0.73 | PTGES2 (0.43) | PTGES2PTGS1KDM4EGAAPTGES | |
| SCHEMBL9156302 | 0.69 | KDM4E (0.46) | PTGES2KDM4EGAATP53MAPT | |
| SCHEMBL12083594 | 0.69 | RORA (0.46) | PTGS1KDM4EGAAMAPTALDH1A1 | |
| SCHEMBL29510573 | 0.68 | NPSR1 (0.59) | PTGS1KDM4EGAAUSP5MAPT | |
| SCHEMBL23612472 | 0.66 | KMO (0.52) | USP2TP53CYP1A2CYP2C9ALOX15 | |
| SCHEMBL24667912 | 0.66 | BCHE (0.45) | PTGS1KDM4EGAAUSP2MAPT | |
| SCHEMBL12889909 | 0.65 | USP5 (0.47) | KDM4EGAAUSP2TP53CYP1A2 | |
| SCHEMBL7907419 | 0.65 | AKR1C2 (0.51) | ARAKR1C4PTGS1AKR1C3AKR1C2 | |
| SCHEMBL879572 | 0.65 | ALDH1A1 (0.59) | USP5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001034199-A2 | ONCOLYTIC COMBINATIONS FOR THE TREATMENT OF CANCER | ELI LILLY AND COMPANY (US) | 2001-05-17 | — | — | WO | claimed |
| WO-2001034199-A2 | ONCOLYTIC COMBINATIONS FOR THE TREATMENT OF CANCER | ELI LILLY AND COMPANY (US) | 2001-05-17 | — | — | WO | disclosed |