SCHEMBL7753903

SCHEMBL7753903

O=C(CN1CCN(c2noc3cc(O)ccc23)CC1)c1ccc(F)cc1

nearest known ligand 0.58

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.51
KDM4E B2RXH2 1/20 0.51
TSHR P16473 1/20 0.51
HTT P42858 1/20 0.51
SMN1; SMN2 Q16637 1/20 0.51
HTR2A P28223 6/20 0.48
DRD2 P14416 5/20 0.48
HTR7 P34969 2/20 0.48
GAA P10253 1/20 0.48
MAPT P10636 2/20 0.46
KCNH2 Q12809 1/20 0.44
CYP1A2 P05177 1/20 0.43
CYP3A4 P08684 1/20 0.43
CYP2D6 P10635 1/20 0.43
CYP2C19 P33261 1/20 0.43
HTR1A P08908 1/20 0.43
KDR P35968 3/20 0.43
DRD4 P21917 1/20 0.42
SIGMAR1 Q99720 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7754666 0.90 DRD2 (0.52) SMN1; SMN2HTR2ADRD2HTR7KCNH2
SCHEMBL7754509 0.88 DRD2 (0.54) TSHRSMN1; SMN2HTR2ADRD2HTR7
Bromide SCHEMBL7754529 0.87 DRD2 (0.53) TSHRSMN1; SMN2HTR2ADRD2HTR7
SCHEMBL7755965 0.87 DRD2 (0.56) TSHRSMN1; SMN2HTR2ADRD2HTR7
Hydrochloric Acid SCHEMBL7755991 0.87 TSHR (0.54) TSHRSMN1; SMN2HTR2ADRD2HTR7
SCHEMBL7754568 0.85 SIGMAR1 (0.57) TSHRSMN1; SMN2HTR2ADRD2HTR7
SCHEMBL7754649 0.80 DRD2 (0.54) TSHRSMN1; SMN2HTR2ADRD2HTR7
SCHEMBL8588378 0.79 HTR2A (0.47) KDM4ETSHRSMN1; SMN2HTR2ADRD2
SCHEMBL8588933 0.79 HTR2A (0.47) HTR2ADRD2HTR7KCNH2HTR1A
Hydrochloric Acid SCHEMBL8587433 0.78 HTR2A (0.47) HTR2ADRD2HTR7KCNH2HTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0833820-B1 BENZISOXAZOLE AND INDAZOLE DERIVATIVES AS ANTIPSYCHOTIC AGENTS AVENTIS PHARMA INC (US) 2001-02-14 EP disclosed
US-6008348-A TREATING A 1-TOSYLATED INDAZOL-3-YL PIPERAZINE DERIVATIVE WITH CONCENTRATED HYDROCHLORIC ACID TO PRODUCE THE DETOSYLATED INDAZOL-3-YL PIPERAZINE COMPOUND OF GIVEN FORMULA HOECHST MARION ROUSSEL, INC. (US) 1999-12-28 US disclosed
US-5965554-A PIPERAZINYLBENZISOXAZOLE DERIVATIVES HOECHST MARION ROUSSEL, INC. (US) 1999-10-12 US disclosed
US-5852022-A Antipsychotic agents, composition and method of use HOECHST ROUSSEL PHARMACEUTICALS INC. (US) 1998-12-22 US disclosed
EP-0833820-A1 BENZISOXAZOLE AND INDAZOLE DERIVATIVES AS ANTIPSYCHOTIC AGENTS HOECHST MARION ROUSSEL, INC. (US) 1998-04-08 EP disclosed
US-5696113-A Antipsychotic agents, compositions and method of use HOECHST MARION ROUSSEL, INC. (US) 1997-12-09 US disclosed
WO-1996039397-A1 BENZISOXAZOLE AND INDAZOLE DERIVATIVES AS ANTIPSYCHOTIC AGENTS HOECHST MARION ROUSSEL, INC. (US) 1996-12-12 WO disclosed