Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 6/20 | 0.47 |
| ▸ | DRD2 | P14416 | 5/20 | 0.47 |
| ▸ | HTR7 | P34969 | 3/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 3/20 | 0.36 |
| ▸ | HTR1F | P30939 | 1/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8588933 | 0.87 | HTR2A (0.47) | HTR2ADRD2HTR7KCNH2SLC6A2 | |
| Bromide SCHEMBL8590676 | 0.86 | HTR2A (0.47) | HTR2ADRD2HTR7KCNH2SLC6A2 | |
| Hydrochloric Acid SCHEMBL8587433 | 0.86 | HTR2A (0.47) | HTR2ADRD2HTR7KCNH2SLC6A2 | |
| SCHEMBL8590828 | 0.85 | SLC6A3 (0.54) | HTR2ADRD2HTR7KCNH2SLC6A2 | |
| SCHEMBL8587254 | 0.84 | SLC6A3 (0.45) | HTR2ADRD2HTR7KCNH2SLC6A2 | |
| SCHEMBL13899001 | 0.80 | KDM4E (0.48) | HTR2ADRD2HTR7KCNH2MEN1 | |
| SCHEMBL8589313 | 0.79 | SLC6A2 (0.43) | HTR2ADRD2HTR7KCNH2SLC6A2 | |
| SCHEMBL7753903 | 0.79 | ALDH1A1 (0.51) | HTR2ADRD2HTR7KCNH2HTR1A | |
| SCHEMBL7754666 | 0.78 | DRD2 (0.52) | HTR2ADRD2HTR7KCNH2HTR1A | |
| SCHEMBL7754509 | 0.76 | DRD2 (0.54) | HTR2ADRD2HTR7HTR1ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5852022-A | Antipsychotic agents, composition and method of use | HOECHST ROUSSEL PHARMACEUTICALS INC. (US) | 1998-12-22 | — | — | US | disclosed |
| US-5696113-A | Antipsychotic agents, compositions and method of use | HOECHST MARION ROUSSEL, INC. (US) | 1997-12-09 | — | — | US | disclosed |