SCHEMBL7754568

SCHEMBL7754568

O=C(CCCN1CCCN(c2noc3cc(O)ccc23)CC1)c1ccc(F)cc1

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 6/20 0.57
TMEM97 Q5BJF2 5/20 0.57
DRD2 P14416 8/20 0.55
DRD4 P21917 8/20 0.55
DRD3 P35462 7/20 0.55
HTR1A P08908 6/20 0.55
HTR2A P28223 6/20 0.55
HTR2C P28335 6/20 0.55
HRH1 P35367 3/20 0.55
SLC6A4 P31645 2/20 0.55
CHRM1 P11229 1/20 0.55
DRD1 P21728 1/20 0.55
HTR2B P41595 1/20 0.55
HTR6 P50406 1/20 0.55
SLC6A3 Q01959 1/20 0.55
HTR7 P34969 3/20 0.55
ADRA2C P18825 1/20 0.51
LMNA P02545 1/20 0.48
CYP1A2 P05177 1/20 0.48
CYP3A4 P08684 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7754509 0.96 DRD2 (0.54) SIGMAR1TMEM97DRD2DRD4DRD3
Hydrochloric Acid SCHEMBL7755991 0.95 TSHR (0.54) SIGMAR1TMEM97DRD2DRD4DRD3
Bromide SCHEMBL7754529 0.95 DRD2 (0.53) SIGMAR1TMEM97DRD2DRD4DRD3
SCHEMBL7755965 0.94 DRD2 (0.56) SIGMAR1TMEM97DRD2DRD4DRD3
SCHEMBL7754666 0.91 DRD2 (0.52) SIGMAR1TMEM97DRD2DRD4DRD3
SCHEMBL7754649 0.89 DRD2 (0.54) SIGMAR1TMEM97DRD2DRD4DRD3
SCHEMBL7753903 0.85 ALDH1A1 (0.51) SIGMAR1DRD2DRD4HTR1AHTR2A
SCHEMBL11082045 0.84 DRD2 (0.66) SIGMAR1TMEM97DRD2DRD4DRD3
SCHEMBL7753495 0.84 ALDH1A1 (0.55) SIGMAR1DRD2DRD4DRD3HTR1A
Hydrochloric Acid SCHEMBL11084263 0.83 DRD2 (0.64) SIGMAR1TMEM97DRD2DRD4DRD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0833820-B1 BENZISOXAZOLE AND INDAZOLE DERIVATIVES AS ANTIPSYCHOTIC AGENTS AVENTIS PHARMA INC (US) 2001-02-14 EP disclosed
US-6008348-A TREATING A 1-TOSYLATED INDAZOL-3-YL PIPERAZINE DERIVATIVE WITH CONCENTRATED HYDROCHLORIC ACID TO PRODUCE THE DETOSYLATED INDAZOL-3-YL PIPERAZINE COMPOUND OF GIVEN FORMULA HOECHST MARION ROUSSEL, INC. (US) 1999-12-28 US disclosed
US-5965554-A PIPERAZINYLBENZISOXAZOLE DERIVATIVES HOECHST MARION ROUSSEL, INC. (US) 1999-10-12 US disclosed