SCHEMBL7756773

SCHEMBL7756773

CCSc1ccccc1/C=N/O

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 7/20 0.41
MAPT P10636 2/20 0.41
FGF23 Q9GZV9 1/20 0.41
USP2 O75604 2/20 0.41
TSHR P16473 3/20 0.40
MAPK1 P28482 1/20 0.40
HSD17B10 Q99714 1/20 0.40
ALDH1A1 P00352 5/20 0.40
LMNA P02545 4/20 0.39
HTT P42858 4/20 0.39
ALOX12 P18054 1/20 0.39
L3MBTL1 Q9Y468 2/20 0.37
MEN1 O00255 1/20 0.36
NPC1 O15118 1/20 0.36
CYP1A2 P05177 1/20 0.36
CYP3A4 P08684 1/20 0.36
CYP2D6 P10635 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
RAB9A P51151 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7756778 1.00 HPGD (0.41) HPGDMAPTFGF23USP2TSHR
SCHEMBL7758675 0.86 PTGS2 (0.44) HPGDMAPTFGF23USP2TSHR
SCHEMBL7758678 0.86 PTGS2 (0.44) HPGDMAPTFGF23USP2TSHR
SCHEMBL1814856 0.79 ALDH1A1 (0.42) HPGDMAPTMAPK1ALDH1A1LMNA
SCHEMBL7754004 0.79 HPGD (0.49) HPGDMAPTFGF23USP2TSHR
SCHEMBL7754006 0.79 HPGD (0.49) HPGDMAPTFGF23USP2TSHR
SCHEMBL5241647 0.79 ALDH1A1 (0.47) HPGDMAPTFGF23TSHRMAPK1
SCHEMBL3260265 0.79 ALDH1A1 (0.47) HPGDMAPTFGF23TSHRMAPK1
SCHEMBL5405571 0.76 ALDH1A1 (0.33) HPGDMAPTTSHRMAPK1HSD17B10
SCHEMBL2801460 0.75 LMNA (0.48) HPGDMAPTTSHRMAPK1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0702008-B1 Method for producing 1,2-benzisothiazol-3-ones SUMITOMO SEIKA CHEMICALS (JP) 2001-08-29 EP disclosed
EP-1081141-A1 Method for producing 1,2-benzisothiazol-3-ones SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) 2001-03-07 EP disclosed
US-5856504-A TREATING A 2-(ALKYLTHIO)BENZALDEHYDE OXIME WITH A HALOGEN COMPOUND SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) 1999-01-05 US disclosed
US-5773626-A HALOGENATION OF A 2-(ALKYLTHIO)BENZALDEHYDE OXIME SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) 1998-06-30 US disclosed
EP-0805151-A1 PROCESSES FOR PRODUCING ISOTHIAZOLE DERIVATIVES SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) 1997-11-05 EP disclosed
US-5633384-A FROM O-ALKYLTHIOBENZONITRILES SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) 1997-05-27 US disclosed
EP-0702008-A2 Method for producing 1,2-benzisothiazol-3-ones SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) 1996-03-20 EP disclosed