Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.41 |
| ▸ | ANPEP | P15144 | 1/20 | 0.39 |
| ▸ | TLR2 | O60603 | 2/20 | 0.39 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.39 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.39 |
| ▸ | PLG | P00747 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.38 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.38 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | ECE1 | P42892 | 1/20 | 0.37 |
| ▸ | CPB1 | P15086 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8645817 | 0.75 | MMP2 (0.47) | MMP2MMP9ANPEPTLR2FOLH1 | |
| SCHEMBL607886 | 0.74 | ITGB3 (0.60) | MMP2MMP9ITGB3ITGA2BFOLH1 | |
| SCHEMBL607885 | 0.74 | ITGB3 (0.60) | MMP2MMP9ITGB3ITGA2BFOLH1 | |
| SCHEMBL7226853 | 0.73 | MMP2 (0.50) | MMP2MMP9ITGB3ITGA2BANPEP | |
| SCHEMBL29005745 | 0.73 | MMP2 (0.50) | MMP2MMP9ANPEPTLR2FOLH1 | |
| SCHEMBL7226850 | 0.73 | MMP2 (0.50) | MMP2MMP9ITGB3ITGA2BANPEP | |
| SCHEMBL30257380 | 0.72 | FOLH1 (0.53) | MMP2MMP9FOLH1CPB2CA1 | |
| SCHEMBL6152839 | 0.72 | MMP2 (0.49) | MMP2MMP9ITGB3ITGA2BANPEP | |
| SCHEMBL5840489 | 0.72 | MMP2 (0.49) | MMP2MMP9ITGB3ITGA2BANPEP | |
| Methane SCHEMBL28261132 | 0.72 | MMP2 (0.49) | MMP2MMP9ITGB3ITGA2BANPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077995-A1 | ANTIANGIOGENIC DRUG TO TREAT CANCER, ARTHRITIS AND RETINOPATHY | ABBOTT LABORATORIES (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999061466-A1 | ANTIANGIOGENIC DRUG TO TREAT CANCER, ARTHRITIS AND RETINOPATHY | ABBOTT LABORATORIES (US) | 1999-12-02 | — | — | WO | disclosed |