Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | CCR5 | P51681 | 2/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.32 |
| ▸ | RELA | Q04206 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.32 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7385061 | 0.94 | LMNA (0.34) | NOTUMCCR5NPC1RAB9AGAA | |
| SCHEMBL7709005 | 0.91 | KDM1A (0.36) | CCR5NPC1RAB9ASMN1; SMN2NFKB1 | |
| SCHEMBL7714804 | 0.85 | HSD17B10 (0.35) | CCR5KDM1AGPR84 | |
| SCHEMBL7376834 | 0.82 | MAPT (0.38) | POLBNPC1RAB9ASMN1; SMN2NFKB1 | |
| SCHEMBL7482499 | 0.78 | NPC1 (0.41) | POLBNPC1RAB9AMAPTMEN1 | |
| SCHEMBL7714495 | 0.76 | PNMT (0.35) | CCR5PLAUNPC1RAB9AKDM1A | |
| SCHEMBL7759563 | 0.75 | CXCR5 (0.32) | CCR5NPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL6756729 | 0.75 | MAOA (0.46) | NOTUMNPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL7712833 | 0.75 | MEN1 (0.37) | CCR5PLAUNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7712647 | 0.74 | LMNA (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1083166-A1 | NOVEL SUBSTITUTED GUANIDINE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2001-03-14 | — | — | EP | disclosed |