Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.45 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7756944 | 0.86 | KDM4E (0.55) | POLBPKMMAPK1KDM4EALDH1A1 | |
| SCHEMBL7761692 | 0.80 | POLB (0.47) | POLBCD274ABCC1PKMMAPK1 | |
| SCHEMBL7761696 | 0.80 | PKM (0.50) | POLBCD274ABCC1PKMMAPK1 | |
| SCHEMBL7761689 | 0.79 | FAAH (0.50) | POLBPKMMAPK1KDM4EALDH1A1 | |
| SCHEMBL1221514 | 0.78 | POLB (0.60) | POLBABCC1PKMMAPK1ALDH1A1 | |
| SCHEMBL30576787 | 0.76 | TAAR1 (0.61) | POLBABCC1PKMMAPK1KDM4E | |
| SCHEMBL6015071 | 0.76 | NPC1 (0.60) | POLBCD274GAASMN1; SMN2KMT2A | |
| SCHEMBL30576775 | 0.73 | POLB (0.60) | POLBABCC1KDM4ESMN1; SMN2KMT2A | |
| SCHEMBL669694 | 0.73 | POLB (0.60) | POLBABCC1KDM4ESMN1; SMN2KMT2A | |
| SCHEMBL651830 | 0.72 | PKM (0.76) | POLBPKMMAPK1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6541479-B1 | Derivatives of thiosalicylic acid and o-aminobenzoic acid | MASSACHUSETTS COLLEGE OF PHARMACY | 2003-04-01 | — | — | US | disclosed |