Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diethylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | F2R | P25116 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diethylamine SCHEMBL7759284 | 0.95 | GRM5 (0.38) | HDAC6HDAC8TP53POLBALDH1A1 | |
| Diethylamine SCHEMBL7762459 | 0.89 | MEN1 (0.36) | HSD17B10TP53CES2POLBALDH1A1 | |
| Diethylamine SCHEMBL8973476 | 0.88 | MEN1 (0.35) | TP53CES2POLBALDH1A1CYP1A2 | |
| Diethylamine SCHEMBL7760658 | 0.88 | HSD17B10 (0.40) | HSD17B10HDAC6HDAC8POLBALDH1A1 | |
| SCHEMBL7760668 | 0.86 | CNR2 (0.41) | TP53ALDH1A1CYP2C19LMNAPKM | |
| Diethylamine SCHEMBL9400404 | 0.85 | POLB (0.37) | HSD17B10POLBALDH1A1CYP2C9LMNA | |
| Diethylamine SCHEMBL7762446 | 0.84 | KMT2A (0.34) | HDAC6TP53CES2HPGDSMN1; SMN2 | |
| Diethylamine SCHEMBL7759271 | 0.84 | GABRA2 (0.35) | HDAC6TP53CES2ALDH1A1HPGD | |
| Diethylamine SCHEMBL7759226 | 0.84 | HSD17B10 (0.34) | HSD17B10HDAC6HDAC8TP53CES2 | |
| SCHEMBL7759279 | 0.82 | GHSR (0.40) | HDAC6ALDH1A1LMNAHTTHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0665462-B1 | Thermofixable photosensitive recording material and process for preparing thereof | NEW OJI PAPER CO LTD (JP) | 2001-04-18 | — | — | EP | disclosed |
| US-5565306-A | SUBSTRATE HAVING RECORDING LAYER CONTAINING PYRAZOLONE DERIVATIVE, HYDROQUINONE DERIVATIVE, ACIDIC SUBSTANCE MUTUALLY DISSOLVED THEREIN | NEW OJI PAPER CO., LTD. (JP) | 1996-10-15 | — | — | US | disclosed |