Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOB | P04114 | 3/20 | 0.34 |
| ▸ | MTTP | P55157 | 3/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 9/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 9/20 | 0.34 |
| ▸ | ACHE | P22303 | 5/20 | 0.32 |
| ▸ | CA1 | P00915 | 4/20 | 0.32 |
| ▸ | CA2 | P00918 | 4/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7907540 | 0.73 | KDM4E (0.39) | — | |
| SCHEMBL431869 | 0.68 | EPHX2 (0.46) | MTNR1AMTNR1BACHECA1CA2 | |
| SCHEMBL1719206 | 0.67 | PIN1 (0.36) | — | |
| SCHEMBL20262067 | 0.66 | GAA (0.39) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL6198272 | 0.66 | ATM (0.33) | — | |
| SCHEMBL7906062 | 0.65 | APOB (0.48) | APOBMTTPMTNR1AMTNR1BACHE | |
| SCHEMBL3862166 | 0.64 | — | — | |
| SCHEMBL6278782 | 0.64 | PIN1 (0.39) | MTNR1AMAPT | |
| SCHEMBL3855140 | 0.64 | SLC6A2 (0.30) | — | |
| SCHEMBL814820 | 0.62 | PDPK1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1097129-A1 | N-BENZOCYCLOALKYL-AMIDE DERIVATIVES AND THEIR USE AS MEDICAMENTS | Novartis AG (CH) | 2001-05-09 | — | — | EP | disclosed |
| US-6197798-B1 | INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN | NOVARTIS AG (CH) | 2001-03-06 | — | — | US | disclosed |
| WO-2000005201-A1 | N-BENZOCYCLOALKYL-AMIDE DERIVATIVES AND THEIR USE AS MEDICAMENTS | NOVARTIS AG (CH) | 2000-02-03 | — | — | WO | disclosed |