SCHEMBL814820

SCHEMBL814820

CC1CCc2cc[c]cc21

nearest known ligand 0.33

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
PDPK1 O15530 1/20 0.33
HTR2A P28223 1/20 0.32
HTR2C P28335 1/20 0.32
HTR2B P41595 1/20 0.32
DRD2 P14416 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5685244 0.88 CHRNB2 (0.37) HTR2AHTR2CHTR2B
SCHEMBL5688182 0.83 HTR2A (0.32) HTR2AHTR2CHTR2B
SCHEMBL1451016 0.78 PGR (0.33) DRD2
SCHEMBL3202689 0.73 MAOA (0.46) DRD2
SCHEMBL17541407 0.72 MTNR1B (0.39)
SCHEMBL4812053 0.72 CHRNB2 (0.30) HTR2AHTR2CHTR2B
SCHEMBL5688247 0.72 PLAU (0.31)
SCHEMBL5685247 0.72 PLAU (0.31)
SCHEMBL1451835 0.72 CHRNB2 (0.55)
SCHEMBL15147096 0.71 HTR2A (0.57) PDPK1HTR2AHTR2CHTR2BDRD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10144791-B2 Molecular weight control of polyolefins using halogenated bis-phenylphenoxy catalysts DOW GLOBAL TECHNOLOGIES LLC (US) 2018-12-04 US claimed
US-20170158790-A1 MOLECULAR WEIGHT CONTROL OF POLYOLEFINS USING HALOGENATED BIS-PHENYLPHENOXY CATALYSTS DOW GLOBAL TECHNOLOGIES LLC 2017-06-08 US claimed
US-8063242-B2 for treatment of neutrofil-dependent pathologies such as psoriasis, ulcerative colitis, melanoma, chronic obstructive pulmonary disease (COPD), bollous pemphigo, rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis; prevention and treatment of damages caused by ischemia and reperfusion DOMPE PHA.R.MA S.P.A. (IT) 2011-11-22 US claimed
US-20050038119-A1 2-Aryl-propionic acids and pharmaceutical compositions containing them DOMPÉ FARMACEUTICI S.P.A. (IT) 2005-02-17 US claimed
EP-1455773-A1 2-ARYL-PROPIONIC ACIDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Dompé S.P.A. (IT) 2004-09-15 EP claimed
WO-2003043625-A1 2-ARYL-PROPIONIC ACIDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM DOMPE S.P.A. (IT) 2003-05-30 WO claimed
EP-3925989-A1 MOLECULAR WEIGHT CONTROL OF POLYOLEFINS USING HALOGENATED BIS-PHENYLPHENOXY CATALYSTS Dow Global Technologies LLC (US) 2021-12-22 EP disclosed
CN-113201084-A Molecular weight control of polyolefins using halogenated bisphenylphenoxy catalysts 陶氏环球技术有限责任公司 2021-08-03 CN disclosed
US-10836697-B2 Process for the preparation of lightly-branched hydrophobes and the corresponding surfactants and applications thereof DOW GLOBAL TECHNOLOGIES LLC (US) 2020-11-17 US disclosed
EP-2797963-B1 HYPERBRANCHED OLEFIN OIL-BASED DIELECTRIC FLUID DOW GLOBAL TECHNOLOGIES LLC (US) 2019-07-03 EP disclosed
US-20190112250-A1 PROCESS FOR THE PREPARATION OF LIGHTLY-BRANCHED HYDROPHOBES AND THE CORRESPONDING SURFACTANTS AND APPLICATIONS THEREOF DOW GLOBAL TECHNOLOGIES LLC (US) 2019-04-18 US disclosed
US-10196336-B2 Process for the preparation of lightly-branched hydrophobes and the corresponding surfactants and applications thereof DOW GLOBAL TECHNOLOGIES LLC (US) 2019-02-05 US disclosed
US-10144791-B2 Molecular weight control of polyolefins using halogenated bis-phenylphenoxy catalysts DOW GLOBAL TECHNOLOGIES LLC (US) 2018-12-04 US disclosed
US-20110282018-A1 PROCESS FOR SELECTIVELY POLYMERIZING ETHYLENE AND CATALYST THEREFOR DOW GLOBAL TECHNOLOGIES LLC 2011-11-17 US disclosed
EP-2229942-A1 2-Aryl-propionic acids and pharmaceutical compositions containing them Dompe S.p.A. (IT) 2010-09-22 EP disclosed
US-20060122064-A1 Amides and method for plant diseases control with the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2006-06-08 US disclosed
EP-1640360-A1 AMIDES AND METHOD FOR PLANT DISEASE CONTROL WITH THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2006-03-29 EP disclosed
US-20050038119-A1 2-Aryl-propionic acids and pharmaceutical compositions containing them DOMPÉ FARMACEUTICI S.P.A. (IT) 2005-02-17 US disclosed
EP-1455773-A1 2-ARYL-PROPIONIC ACIDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Dompé S.P.A. (IT) 2004-09-15 EP disclosed
WO-2003043625-A1 2-ARYL-PROPIONIC ACIDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM DOMPE S.P.A. (IT) 2003-05-30 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10836697-B2 Process for the preparation of lightly-branched hydrophobes and the corresponding surfactants and applications thereof ERG28, CLTB, CHN2 PDPK1 4586/4885HTR2A 3957/4885HTR2C 3367/4885
US-20060122064-A1 Amides and method for plant diseases control with the same ARG1, ARGLU1, ARG2 PDPK1 4243/4885HTR2A 3356/4885HTR2C 3581/4885
US-10196336-B2 Process for the preparation of lightly-branched hydrophobes and the corresponding surfactants and applications thereof ERG28, CLTB, CHN2 PDPK1 4586/4885HTR2A 3957/4885HTR2C 3367/4885
US-20110282018-A1 PROCESS FOR SELECTIVELY POLYMERIZING ETHYLENE AND CATALYST THEREFOR WEE2, NOTUM, WEE1 PDPK1 1470/4885HTR2A 4613/4885HTR2C 4012/4885
US-20190112250-A1 PROCESS FOR THE PREPARATION OF LIGHTLY-BRANCHED HYDROPHOBES AND THE CORRESPONDING SURFACTANTS AND APPLICATIONS THEREOF ERG28, CLTB, CHN2 PDPK1 4604/4885HTR2A 3955/4885HTR2C 3410/4885
US-20050038119-A1 2-Aryl-propionic acids and pharmaceutical compositions containing them CXCR2, FPR1, CCR2 PDPK1 1100/4885HTR2A 1663/4885HTR2C 1920/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.