Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 4/20 | 0.55 |
| ▸ | MMP3 | P08254 | 3/20 | 0.55 |
| ▸ | MMP7 | P09237 | 1/20 | 0.55 |
| ▸ | MMP9 | P14780 | 3/20 | 0.52 |
| ▸ | MMP2 | P08253 | 2/20 | 0.52 |
| ▸ | MMP14 | P50281 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | PLAU | P00749 | 4/20 | 0.46 |
| ▸ | HPN | P05981 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7758531 | 0.90 | MMP1 (0.69) | MMP1MMP3MMP7MMP9MMP2 | |
| SCHEMBL6806856 | 0.90 | MMP1 (0.69) | MMP1MMP3MMP7MMP9MMP2 | |
| SCHEMBL7762157 | 0.83 | MMP2 (0.58) | MMP1MMP3MMP2 | |
| SCHEMBL7763096 | 0.81 | MMP3 (0.80) | MMP1MMP3MMP7MMP9MMP2 | |
| SCHEMBL7758581 | 0.79 | MMP3 (0.61) | MMP1MMP3MMP7MMP9MMP2 | |
| SCHEMBL7762136 | 0.71 | MMP1 (1.00) | MMP1MMP3MMP7MMP9MMP2 | |
| SCHEMBL7763578 | 0.71 | MMP1 (0.58) | MMP1MMP3MMP7MMP9MMP2 | |
| SCHEMBL27335561 | 0.70 | NPY5R (0.43) | MMP1MMP3MMP7MMP9MMP2 | |
| SCHEMBL9284470 | 0.69 | MMP2 (1.00) | MMP1MMP3MMP7MMP9MMP2 | |
| SCHEMBL6713855 | 0.69 | MAPT (0.56) | ALDH1A1NPC1SMN1; SMN2EPHX2PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098662-A2 | COADMINISTRATION OF ACAT AND MMP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROTIC LESIONS | WARNER-LAMBERT COMPANY (US) | 2001-05-16 | — | — | EP | claimed |
| WO-2000004892-A2 | COADMINISTRATION OF ACAT AND MMP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROTIC LESIONS | WARNER-LAMBERT COMPANY (US) | 2000-02-03 | — | — | WO | claimed |
| EP-1098662-A2 | COADMINISTRATION OF ACAT AND MMP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROTIC LESIONS | WARNER-LAMBERT COMPANY (US) | 2001-05-16 | — | — | EP | disclosed |
| WO-2000004892-A2 | COADMINISTRATION OF ACAT AND MMP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROTIC LESIONS | WARNER-LAMBERT COMPANY (US) | 2000-02-03 | — | — | WO | disclosed |