Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.43 |
| ▸ | C1R | P00736 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16982969 | 0.78 | RAB9A (0.56) | PIK3CGPIK3CAPIK3CBGAARAB9A | |
| SCHEMBL3956226 | 0.78 | TSHR (0.62) | HDAC3HDAC1HDAC2HDAC6CYP2C19 | |
| SCHEMBL8973265 | 0.77 | TSHR (0.56) | HDAC3HDAC1HDAC2HDAC6RAPGEF4 | |
| SCHEMBL4911297 | 0.77 | TSHR (0.61) | HDAC3HDAC1HDAC2HDAC6RAPGEF4 | |
| SCHEMBL28117162 | 0.76 | GAA (0.41) | HDAC3HDAC1HDAC2HDAC6RAPGEF4 | |
| SCHEMBL14577629 | 0.74 | AURKA (0.63) | CYP2C9CYP1A2CYP3A4CYP2C19RAB9A | |
| SCHEMBL7811449 | 0.74 | PIK3CG (0.64) | PIK3CGPIK3CAPIK3CBRET | |
| SCHEMBL9738354 | 0.74 | RAPGEF4 (0.53) | HDAC3HDAC1HDAC2HDAC6RAPGEF4 | |
| SCHEMBL9505944 | 0.74 | HDAC3 (0.50) | HDAC3HDAC1HDAC2HDAC6RAPGEF4 | |
| SCHEMBL18710703 | 0.74 | CRHR1 (0.43) | PIK3CGPIK3CAPIK3CBRAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1107957-A1 | PYRIMIDINE COMPOUNDS | AstraZeneca AB (SE) | 2001-06-20 | — | — | EP | claimed |
| WO-2000012485-A1 | PYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2000-03-09 | — | — | WO | claimed |
| EP-1107957-A1 | PYRIMIDINE COMPOUNDS | AstraZeneca AB (SE) | 2001-06-20 | — | — | EP | disclosed |
| WO-2000012485-A1 | PYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2000-03-09 | — | — | WO | disclosed |