Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 9/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | UBE2M | P61081 | 1/20 | 0.40 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7765119 | 0.76 | OPRM1 (0.41) | MAPTALDH1A1KDM4E | |
| SCHEMBL7763658 | 0.74 | MMP2 (0.47) | RAB9ANPC1MAPTALDH1A1GAA | |
| SCHEMBL7761478 | 0.74 | MAPT (0.42) | RAB9ANPC1MAPTALDH1A1GAA | |
| SCHEMBL2839287 | 0.72 | RAB9A (0.74) | RAB9ANPC1MAPTALDH1A1KDM4E | |
| SCHEMBL29134529 | 0.71 | RAB9A (0.64) | RAB9ANPC1MAPTALDH1A1KDM4E | |
| SCHEMBL29134528 | 0.71 | RAB9A (0.64) | RAB9ANPC1MAPTALDH1A1KDM4E | |
| SCHEMBL7102154 | 0.69 | HDAC3 (0.70) | RAB9ANPC1MAPTALDH1A1KDM4E | |
| SCHEMBL7765074 | 0.69 | MMP2 (0.51) | RAB9ANPC1 | |
| SCHEMBL7761465 | 0.68 | MMP1 (0.43) | RAB9ANPC1MAPTLMNA | |
| SCHEMBL11446436 | 0.67 | KMT2A (0.50) | RAB9AMAPTALDH1A1GAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098662-A2 | COADMINISTRATION OF ACAT AND MMP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROTIC LESIONS | WARNER-LAMBERT COMPANY (US) | 2001-05-16 | — | — | EP | claimed |
| WO-2000004892-A2 | COADMINISTRATION OF ACAT AND MMP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROTIC LESIONS | WARNER-LAMBERT COMPANY (US) | 2000-02-03 | — | — | WO | claimed |