Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.48 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.46 |
| ▸ | THRA | P10827 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17154344 | 0.83 | ALOX15 (0.55) | ALOX15PTPN1ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL5004504 | 0.82 | ALOX15 (0.70) | ALOX15PTPN1ALDH1A1FFAR1MEN1 | |
| SCHEMBL7768967 | 0.80 | ALDH1A1 (0.46) | ALOX15PTPN1ALDH1A1CYP1A2TSHR | |
| SCHEMBL11377919 | 0.79 | LMNA (0.56) | ALOX15PTPN1ALDH1A1ADRB1ADRB3 | |
| SCHEMBL339492 | 0.78 | ALOX15 (0.81) | ALOX15ALDH1A1TSHRSMN1; SMN2FFAR1 | |
| SCHEMBL9782055 | 0.77 | ALOX15 (0.57) | ALOX15PTPN1ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL4781395 | 0.77 | ALOX15 (0.61) | ALOX15ALDH1A1TSHRSMN1; SMN2FFAR1 | |
| SCHEMBL2439826 | 0.75 | ALOX15 (0.59) | ALOX15ALDH1A1TSHRSMN1; SMN2FFAR1 | |
| SCHEMBL10702376 | 0.75 | ALDH1A1 (0.57) | ALOX15ALDH1A1ADRB1ADRB3CYP1A2 | |
| SCHEMBL9832704 | 0.74 | ALOX15 (0.63) | ALOX15ALDH1A1TSHRSMN1; SMN2FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741128-B1 | Sulphuric acid esters of sugar alcohols for the inhibition of the migration and proliferation of smooth muscle cells of the vascular walls | HOFFMANN LA ROCHE (CH) | 2001-06-20 | — | — | EP | disclosed |
| EP-0741128-A2 | Sulphuric acid esters of sugar alcohols for the inhibition of the migration and proliferation of smooth muscle cells of the vascular walls | F. HOFFMANN-LA ROCHE AG (CH) | 1996-11-06 | — | — | EP | disclosed |