Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 4/20 | 0.48 |
| ▸ | S1PR2 | O95136 | 3/20 | 0.48 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.48 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.45 |
| ▸ | THRA | P10827 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.43 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 5/20 | 0.42 |
| ▸ | PPARD | Q03181 | 5/20 | 0.42 |
| ▸ | PPARA | Q07869 | 5/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TLR2 | O60603 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | FABP4 | P15090 | 2/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adipic Acid SCHEMBL7764425 | 0.96 | FFAR4 (0.51) | S1PR1S1PR2S1PR3FFAR4FFAR1 | |
| Malonic Acid SCHEMBL7765984 | 0.91 | S1PR1 (0.43) | S1PR1S1PR2S1PR3THRATHRB | |
| Acetic Acid SCHEMBL7764900 | 0.91 | THRA (0.42) | S1PR1S1PR2S1PR3FFAR1THRA | |
| Succinic Acid SCHEMBL7764866 | 0.89 | S1PR2 (0.41) | S1PR1S1PR2S1PR3FFAR4FFAR1 | |
| Lactic Acid SCHEMBL7768220 | 0.88 | GPR84 (0.45) | S1PR1S1PR2S1PR3FFAR1THRA | |
| Cadaverine Tartrate SCHEMBL7764537 | 0.87 | GPR84 (0.44) | S1PR1S1PR2S1PR3FFAR1THRA | |
| Hydrochloric Acid SCHEMBL8719708 | 0.86 | THRA (0.37) | THRATHRBALDH1A1ESR1HSD17B10 | |
| Hydrochloric Acid SCHEMBL7760906 | 0.86 | THRA (0.37) | THRATHRBALDH1A1ESR1HSD17B10 | |
| Hydrochloric Acid SCHEMBL7764492 | 0.86 | THRA (0.37) | THRATHRBALDH1A1ESR1HSD17B10 | |
| Succinic Acid SCHEMBL7764851 | 0.86 | CYSLTR2 (0.50) | S1PR1S1PR2S1PR3FFAR4FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0825175-B1 | Quaternary ammonium disinfectant | NICCA CHEMICAL CO (JP) | 2001-06-13 | — | — | EP | disclosed |
| EP-0825175-A1 | Quaternary ammonium disinfectant | NICCA CHEMICAL CO., LTD. (JP) | 1998-02-25 | — | — | EP | disclosed |