Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.62 |
| ▸ | NSD2 | O96028 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | SLC40A1 | Q9NP59 | 3/20 | 0.51 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | CASP1 | P29466 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7768609 | 0.80 | KDM4E (0.67) | KDM4ENSD2TSHRHSD17B10ALDH1A1 | |
| SCHEMBL16110825 | 0.71 | ALDH1A1 (0.68) | KDM4ENSD2TSHRHSD17B10ALDH1A1 | |
| SCHEMBL2762847 | 0.71 | SMN1; SMN2 (0.62) | KDM4ENSD2TSHRHSD17B10ALDH1A1 | |
| SCHEMBL7770284 | 0.70 | RORA (0.54) | KDM4ENSD2TSHRHSD17B10LMNA | |
| SCHEMBL11240120 | 0.70 | MEN1 (0.43) | KDM4EHSD17B10ALDH1A1MEN1KMT2A | |
| SCHEMBL17559543 | 0.69 | SLC22A12 (0.60) | ALDH1A1MEN1KMT2ARXFP1SLC40A1 | |
| SCHEMBL29023903 | 0.69 | EDNRA (0.60) | KDM4ENSD2TSHRHSD17B10ALDH1A1 | |
| SCHEMBL4617033 | 0.69 | ALDH1A1 (0.54) | KDM4ENSD2TSHRHSD17B10ALDH1A1 | |
| SCHEMBL11217498 | 0.69 | NR1H2 (0.43) | KDM4EHSD17B10MEN1KMT2ASLC22A12 | |
| SCHEMBL11248862 | 0.69 | TRPV4 (0.42) | KDM4EHSD17B10ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5641793-A | POSSESS ENDOTHELIN RECEPTOR ANTAGONIST ACTIVITY; USEFUL IN TREATMENT OF HYPERTENSION, CARDIAC OR CEREBRAL CIRCULATORY DISEASE AND RENAL DISEASE | ZENECA LIMITED (GB) | 1997-06-24 | — | — | US | claimed |