Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 7/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | GPR3 | P46089 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.42 |
| ▸ | TUBB | P07437 | 2/20 | 0.42 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.42 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31536922 | 0.82 | ALOX5 (0.39) | ALDH1A1KDM4EMAPK1SMN1; SMN2MAPT | |
| SCHEMBL13713800 | 0.79 | GPR3 (0.46) | ALDH1A1KDM4EMAPK1SMN1; SMN2MAPT | |
| SCHEMBL22366331 | 0.79 | ALDH1A1 (0.50) | ALDH1A1KDM4EMAPK1SMN1; SMN2MAPT | |
| SCHEMBL31536923 | 0.78 | GPR3 (0.44) | ALDH1A1KDM4EMAPK1SMN1; SMN2MAPT | |
| SCHEMBL30557573 | 0.78 | ALDH1A1 (0.48) | ALDH1A1KDM4EMAPK1SMN1; SMN2MAPT | |
| SCHEMBL25383926 | 0.78 | ALDH1A1 (0.48) | ALDH1A1KDM4EMAPK1SMN1; SMN2MAPT | |
| SCHEMBL6408883 | 0.73 | CNR2 (0.44) | ALDH1A1KDM4EMAPK1SMN1; SMN2MAPT | |
| SCHEMBL10421946 | 0.73 | ALDH1A1 (0.43) | ALDH1A1KDM4EMAPK1SMN1; SMN2MAPT | |
| SCHEMBL8323182 | 0.73 | TUBB4A (0.48) | ALDH1A1KDM4EMAPK1SMN1; SMN2MAPT | |
| SCHEMBL5440971 | 0.73 | GPR3 (0.40) | ALDH1A1KDM4EMAPK1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022002077-A1 | ARYL AROMATIC HETEROCYCLIC DERIVATIVE AND PREPARATION METHOD THEREFOR AND USE THEREOF | 上海海和药物研究开发股份有限公司 | 2022-01-06 | — | — | WO | disclosed |
| US-9206201-B2 | Boronic acid bearing liphagane compounds as inhibitors of P13K-α and/or β | COUNSEL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2015-12-08 | — | — | US | disclosed |
| US-20150051173-A1 | BORONIC ACID BEARING LIPHAGANE COMPOUNDS AS INHIBITORS OF P13K- a AND/OR B | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2015-02-19 | — | — | US | disclosed |
| EP-0693488-B1 | An improved process for preparing 3-(4-aminoethoxy-benzoyl)benzo beta -thiophenes | LILLY CO ELI (US) | 2001-09-19 | — | — | EP | disclosed |
| US-5994547-A | Process for preparing benzo[b]thiophenes | ELI LILLY AND COMPANY (US) | 1999-11-30 | — | — | US | disclosed |
| EP-0875511-A1 | Demethylation process for preparing benzo[b]thiophenes | ELI LILLY AND COMPANY (US) | 1998-11-04 | — | — | EP | disclosed |
| US-5523416-A | Process for preparing 3-(4-aminoethoxy-benzoyl) benzo (B)-thiophenes | ELI LILLY AND COMPANY (US) | 1996-06-04 | — | — | US | disclosed |
| EP-0693488-A1 | An improved process for preparing 3-(4-aminoethoxy-benzoyl)benzo beta -thiophenes | ELI LILLY AND COMPANY (US) | 1996-01-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150051173-A1 | BORONIC ACID BEARING LIPHAGANE COMPOUNDS AS INHIBITORS OF P13K- a AND/OR B | PIK3CA, PIK3C2A, PI4KA | ALDH1A1 3574/4885KDM4E 985/4885MAPK1 53/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.