Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 3/20 | 0.48 |
| ▸ | KCNA3 | P22001 | 2/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | DRD3 | P35462 | 2/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15587141 | 0.91 | KCNN4 (0.46) | KCNN4KCNA3SLC6A2SLC6A4ADRB1 | |
| SCHEMBL569963 | 0.82 | SIGMAR1 (0.48) | ADRB1CYP1A2CYP2D6CHRM2CHRM4 | |
| SCHEMBL8411629 | 0.81 | SIGMAR1 (0.47) | ADRB1CYP1A2CYP2D6CHRM2CHRM4 | |
| SCHEMBL9090858 | 0.81 | SIGMAR1 (0.47) | ADRB1CYP1A2CYP2D6CHRM2CHRM4 | |
| SCHEMBL5280949 | 0.81 | KCNN4 (0.48) | KCNN4KCNA3SLC6A2SLC6A4ADRB1 | |
| SCHEMBL2491431 | 0.81 | ADRB1 (0.49) | SLC6A2SLC6A4ADRB1CYP1A2CYP2D6 | |
| SCHEMBL2491597 | 0.81 | CHRM2 (0.40) | SLC6A2SLC6A4ADRB1SLC6A3CYP2D6 | |
| SCHEMBL7336645 | 0.79 | HTR7 (0.49) | ADRB1CYP1A2CHRM2CHRM4CHRM1 | |
| SCHEMBL7777404 | 0.78 | KCNN4 (0.46) | KCNN4KCNA3SLC6A2SLC6A4ADRB1 | |
| SCHEMBL2490245 | 0.77 | HTR3A (0.49) | SLC6A2SLC6A4ADRB1SLC6A3CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0574906-B1 | Piperazine and homopiperazine derivatives, pharmaceutical compositions containing them and process for preparing the same | NISSHIN FLOUR MILLING CO (JP) | 2001-08-22 | — | — | EP | disclosed |
| US-5380724-A | Inhibitors of lipid peroxidation | GYOGYSZERKUTATO INTEZET KFT (HU) | 1995-01-10 | — | — | US | disclosed |
| EP-0574906-A2 | Piperazine and homopiperazine derivatives, pharmaceutical compositions containing them and process for preparing the same | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1993-12-22 | — | — | EP | disclosed |