Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 5/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | ATM | Q13315 | 2/20 | 0.35 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 2/20 | 0.34 |
| ▸ | GABRD | O14764 | 2/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7068692 | 0.88 | ADRB2 (0.39) | KDM4EALDH1A1HPGDADRB2HSD17B10 | |
| SCHEMBL7070291 | 0.88 | ADRB2 (0.38) | KDM4EALDH1A1HPGDADRB2HSD17B10 | |
| SCHEMBL7069437 | 0.83 | KDM4E (0.42) | KDM4EALDH1A1HPGDADRB2HSD17B10 | |
| SCHEMBL6905932 | 0.83 | CTSV (0.41) | KDM4EALDH1A1HPGDADRB2UTS2R | |
| SCHEMBL7778754 | 0.80 | ADRB2 (0.43) | KDM4EADRB2KMT2AMAPTATM | |
| SCHEMBL7781300 | 0.78 | NR1I2 (0.33) | KDM4EALDH1A1HPGDADRB2HSD17B10 | |
| SCHEMBL7072937 | 0.76 | KIF11 (0.36) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL7778751 | 0.72 | ADRB2 (0.49) | KDM4EALDH1A1ADRB2KMT2AMAPT | |
| SCHEMBL7983732 | 0.71 | TP53 (0.39) | KDM4EALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL7070543 | 0.71 | MTNR1A (0.50) | KDM4EALDH1A1HPGDHSD17B10KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1128845-A1 | COMBINATIONS COMPRISING A BETA-AGONIST AND A FURTHER ANTDIABETIC AGENT | SMITHKLINE BEECHAM PLC (GB) | 2001-09-05 | — | — | EP | disclosed |
| WO-2000027434-A1 | COMBINATIONS COMPRISING A BETA-AGONIST AND A FURTHER ANTIDIABETIC AGENT | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-05-18 | — | — | WO | disclosed |