SCHEMBL7779423

SCHEMBL7779423

Nc1ccc(OC(F)(F)F)c(F)c1

nearest known ligand 0.50

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 6/20 0.50
PDE2A O00408 2/20 0.50
SLC7A5 Q01650 1/20 0.40
GLA P06280 1/20 0.38
POLB P06746 1/20 0.38
GAA P10253 1/20 0.38
TSHR P16473 1/20 0.38
HCRTR1 O43613 2/20 0.36
HCRTR2 O43614 2/20 0.36
KIF11 P52732 1/20 0.36
ALOX5AP P20292 1/20 0.35
FEN1 P39748 1/20 0.35
MPL P40238 1/20 0.34
CTSK P43235 1/20 0.34
NAAA Q02083 1/20 0.34
ABL1 P00519 1/20 0.34
HRH4 Q9H3N8 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29974520 1.00 EPHX2 (0.50) EPHX2PDE2ASLC7A5GLAPOLB
SCHEMBL29029528 0.89 EPHX2 (0.46) EPHX2PDE2ASLC7A5GLAPOLB
SCHEMBL9125985 0.84 PDE2A (0.37) EPHX2PDE2ASLC7A5GLAPOLB
SCHEMBL734531 0.83 IDO1 (0.40) EPHX2PDE2AGLAPOLBGAA
SCHEMBL9367414 0.83 GAA (0.40) EPHX2PDE2AGLAPOLBGAA
SCHEMBL9447622 0.82 KDM4E (0.45) EPHX2PDE2ASLC7A5GLAPOLB
SCHEMBL27530767 0.82 PDE2A (0.41) EPHX2PDE2AGLAPOLBGAA
SCHEMBL9224896 0.81 TSHR (0.43) EPHX2PDE2AGLAPOLBGAA
SCHEMBL398001 0.81 ALDH1A1 (0.44) EPHX2PDE2AGLAPOLBGAA
SCHEMBL5502229 0.81 ALDH1A1 (0.44) EPHX2PDE2AGLAPOLBGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 149 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0315862-B1 Aromatically fluorinated fluoromethoxy- and fluoromethylthio-amino benzenes and their preparation BAYER AG (DE) 1994-04-13 EP claimed
EP-0315862-A2 Aromatically fluorinated fluoromethoxy- and fluoromethylthio-amino benzenes and their preparation BAYER AG (DE) 1989-05-17 EP claimed
JP-1149755-A None JP disclosed
WO-2025217430-A1 HETEROCYCLIC COMPOUNDS AS NRAS INHIBITORS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2025-10-16 WO disclosed
EP-4612130-A1 POLYMORPHIC FORMS OF A SOLUBLE EPOXIDE HYDROLASE INHIBITOR AND FORMULATIONS THEREOF Eicosis, LLC (US) 2025-09-10 EP disclosed
US-20250263366-A2 CASPASE 6 INHIBITORS AND USES THEREOF SHANGPHARMA INNOVATION INC. 2025-08-21 US disclosed
EP-4563573-A1 COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF IN PREPARATION OF SEH INHIBITOR AND PPARS AGONIST Shenyang Pharmaceutical University (CN) 2025-06-04 EP disclosed
WO-2025054339-A1 TRIAZOLOPYRIDINE COMPOUNDS AS INHIBITORS OF KIT ARCUS BIOSCIENCES, INC. (US) 2025-03-13 WO disclosed
EP-4139286-B1 SUBSTITUTED AMINOTHIAZOLES AS DGKZETA INHIBITORS FOR IMMUNE ACTIVATION BAYER AG (DE) 2025-02-26 EP disclosed
CN-119241440-A Indazole benzoic acid derivative containing urea structure and preparation method and application thereof 沈阳药科大学 2025-01-03 CN disclosed
WO-2024193129-A1 COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF IN PREPARATION OF SEH INHIBITOR AND PPARS AGONIST 沈阳药科大学 2024-09-26 WO disclosed
EP-0637623-B1 Cyclic hydrocarbon derivative and liquid crystal composition containing the same DAINIPPON INK & CHEMICALS (JP) 2001-10-04 EP disclosed
US-5536443-A DUTERIUM CONTAINING COMPOUNDS FOOR ELECTROOPTICAL APPARATUS DAINIPPON INK & CHEMICALS, INC. (JP) 1996-07-16 US disclosed
US-5474707-A Electrooptic display DAINIPPON INK AND CHEMICALS, INC. (JP) 1995-12-12 US disclosed
EP-0637623-A1 Cyclic hydrocarbon derivative and liquid crystal composition containing the same DAINIPPON INK AND CHEMICALS, INC. (JP) 1995-02-08 EP disclosed
EP-0315862-B1 Aromatically fluorinated fluoromethoxy- and fluoromethylthio-amino benzenes and their preparation BAYER AG (DE) 1994-04-13 EP disclosed
EP-0521365-A1 Acetanilides NIHON BAYER AGROCHEM K.K. (JP) 1993-01-07 EP disclosed
JP-H01149755-A FLUOROMETHOXY-AMINOBENEZNES AND FLUOROMETHYLTHIO-AMINOBENZENES CONTAINING FLUORINE IN AROMATIC NUCLEUS AND THEIR PRODUCTION BAYER AG 1989-06-12 JP disclosed
EP-0318704-A2 3-Cyano-4-phenyl-pyrrole derivatives BAYER AG (DE) 1989-06-07 EP disclosed
EP-0315862-A2 Aromatically fluorinated fluoromethoxy- and fluoromethylthio-amino benzenes and their preparation BAYER AG (DE) 1989-05-17 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250263366-A2 CASPASE 6 INHIBITORS AND USES THEREOF CASP6, CASP1, CASP10 EPHX2 3551/4885PDE2A 2028/4885SLC7A5 4708/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.