Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 3/20 | 0.41 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 10/20 | 0.39 |
| ▸ | BRAF | P15056 | 5/20 | 0.38 |
| ▸ | LIPE | Q05469 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.37 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
| ▸ | PLA2G7 | Q13093 | 2/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7781117 | 0.92 | KMO (0.43) | RAF1MAPK3KDRBRAFLIPE | |
| SCHEMBL7783738 | 0.89 | KDR (0.39) | KDRBRAFLIPEARMAPK14 | |
| SCHEMBL7783034 | 0.85 | RAF1 (0.42) | RAF1MAPK3KDRBRAFPLA2G7 | |
| SCHEMBL7776082 | 0.83 | KDR (0.46) | RAF1KDRBRAFLIPEMAPK14 | |
| SCHEMBL7782975 | 0.81 | RAF1 (0.39) | RAF1MAPK3KDRBRAFKMO | |
| SCHEMBL7780252 | 0.79 | KDR (0.48) | RAF1MAPK3KDRBRAFLIPE | |
| SCHEMBL7056169 | 0.76 | KDR (0.40) | RAF1MAPK3KDRBRAFMAPK14 | |
| SCHEMBL7885604 | 0.76 | RAF1 (0.49) | RAF1MAPK3KDRBRAFKMO | |
| SCHEMBL7776101 | 0.73 | KDR (0.42) | RAF1MAPK3KDRBRAFPLA2G7 | |
| SCHEMBL7781138 | 0.73 | KDR (0.42) | RAF1MAPK3KDRBRAFPLA2G7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0972770-B1 | Acaricidal and insecticidal substituted pyrimidines and a process for the preparation thereof | BASF AG (DE) | 2001-09-19 | — | — | EP | claimed |
| EP-0972770-B1 | Acaricidal and insecticidal substituted pyrimidines and a process for the preparation thereof | BASF AG (DE) | 2001-09-19 | — | — | EP | disclosed |
| US-6281219-B1 | 4,6-BIS-ARYL-PYRIMIDINES WHEREIN THE AROMATIC GROUPS ARE ATTACHED VIA TWO LINKING GROUPS WHICH ARE DIFFERENT FROM ONE ANOTHER. | AMERICAN CYANAMID CO. | 2001-08-28 | — | — | US | disclosed |
| EP-0972770-A1 | Acaricidal and insecticidal substituted pyrimidines and a process for the preparation thereof | American Cyanamid Company (US) | 2000-01-19 | — | — | EP | disclosed |