Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.49 |
| ▸ | HTR1A | P08908 | 4/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5203306 | 0.94 | HTR1A (0.50) | HTR1ASLC6A4 | |
| SCHEMBL7787595 | 0.91 | DRD2 (0.47) | DRD2HTR1ASLC6A4 | |
| SCHEMBL7784865 | 0.90 | HTR1A (0.49) | DRD2HTR1ASLC6A4KCNH2 | |
| SCHEMBL7784880 | 0.90 | HTR1A (0.44) | DRD2HTR1A | |
| SCHEMBL7787373 | 0.90 | KDM4E (0.47) | DRD2HTR1A | |
| SCHEMBL7787585 | 0.88 | HTR1A (0.51) | DRD2HTR1ASLC6A4HTR6KCNH2 | |
| SCHEMBL7784858 | 0.88 | ADRA2A (0.53) | DRD2HTR1A | |
| SCHEMBL8125493 | 0.88 | DRD2 (0.47) | DRD2HTR1AHTR6KCNH2 | |
| SCHEMBL7784884 | 0.85 | DRD2 (0.57) | DRD2HTR1ASLC6A4HTR6KCNH2 | |
| SCHEMBL7785392 | 0.85 | SLC6A4 (0.53) | HTR1ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1093127-C | Piperazine derivatives | MERCK PATENT GMBH (DE) | 2002-10-23 | — | — | CN | disclosed |
| US-6251908-B1 | Piperazine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2001-06-26 | — | — | US | disclosed |
| CN-1264379-A | Piperazine derivatives | MERCK PATENT GMBH (DE) | 2000-08-23 | — | — | CN | disclosed |
| EP-0998474-A1 | PIPERAZINE DERIVATIVES | MERCK PATENT GmbH (DE) | 2000-05-10 | — | — | EP | disclosed |
| WO-1999003855-A1 | PIPERAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 1999-01-28 | — | — | WO | disclosed |