Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 1/20 | 0.43 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CASR | P41180 | 2/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7785127 | 0.87 | ALDH1A1 (0.41) | KRASSOS1ACHECA1CA2 | |
| SCHEMBL7780432 | 0.87 | ALDH1A1 (0.41) | KRASSOS1ACHECA1CA2 | |
| SCHEMBL7780640 | 0.87 | ALDH1A1 (0.41) | KRASSOS1ACHECA1CA2 | |
| SCHEMBL27553525 | 0.85 | PDPK1 (0.39) | KRASSOS1CASRSMN1; SMN2TDP1 | |
| SCHEMBL7784936 | 0.85 | PDPK1 (0.39) | KRASSOS1CASRSMN1; SMN2TDP1 | |
| SCHEMBL7780509 | 0.84 | MAPKAPK2 (0.34) | KRASSOS1L3MBTL1ALDH1A1KMT2A | |
| SCHEMBL7785234 | 0.84 | MAPKAPK2 (0.34) | KRASSOS1L3MBTL1ALDH1A1KMT2A | |
| SCHEMBL7784937 | 0.84 | KRAS (0.37) | KRASSOS1ACHECA1CA2 | |
| SCHEMBL7780705 | 0.83 | LMNA (0.34) | KRASSOS1SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL7785101 | 0.83 | ADRB2 (0.36) | KRASSOS1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | disclosed |
| CN-1287117-A | Cyclobutene derivatives, preparation method and therapeutic use thereof | SANKYO CO (JP) | 2001-03-14 | — | — | CN | disclosed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |