Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | KRAS | P01116 | 1/20 | 0.32 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7785234 | 1.00 | MAPKAPK2 (0.34) | MAPKAPK2PDPK1KRASSOS1MAPK1 | |
| SCHEMBL27553525 | 0.93 | PDPK1 (0.39) | MAPKAPK2PDPK1KRASSOS1MAPK1 | |
| SCHEMBL7784936 | 0.93 | PDPK1 (0.39) | MAPKAPK2PDPK1KRASSOS1MAPK1 | |
| SCHEMBL7785101 | 0.91 | ADRB2 (0.36) | MAPKAPK2PDPK1KRASSOS1MAPK1 | |
| SCHEMBL7780705 | 0.91 | LMNA (0.34) | MAPKAPK2PDPK1KRASSOS1MAPK1 | |
| SCHEMBL7785553 | 0.91 | LMNA (0.34) | MAPKAPK2PDPK1KRASSOS1MAPK1 | |
| SCHEMBL7784915 | 0.90 | TRPM8 (0.32) | MAPKAPK2KRASSOS1CYP3A4CYP2D6 | |
| SCHEMBL7785470 | 0.90 | TRPM8 (0.32) | MAPKAPK2KRASSOS1CYP3A4CYP2D6 | |
| SCHEMBL7787788 | 0.89 | CASR (0.37) | MAPKAPK2MAPK1SLC6A2SLC6A4ALDH1A1 | |
| SCHEMBL7787609 | 0.89 | MAPKAPK2 (0.45) | MAPKAPK2PDPK1KRASSOS1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | disclosed |
| CN-1287117-A | Cyclobutene derivatives, preparation method and therapeutic use thereof | SANKYO CO (JP) | 2001-03-14 | — | — | CN | disclosed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |