Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB8 | P28062 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | DAO | P14920 | 2/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7782299 | 0.78 | PDE7A (0.45) | RXFP1ADORA3MEN1CYP1A2KMT2A | |
| SCHEMBL4706735 | 0.77 | PSMB8 (0.55) | PSMB8NPSR1RXFP1ADORA3ADORA1 | |
| SCHEMBL29580191 | 0.77 | PSMB8 (0.55) | PSMB8NPSR1RXFP1ADORA3ADORA1 | |
| SCHEMBL7783672 | 0.73 | LMNA (0.43) | ADORA3ADORA1ADORA2BMEN1KMT2A | |
| SCHEMBL104742 | 0.72 | LMNA (0.63) | PSMB8NPSR1RXFP1ADORA3ADORA1 | |
| SCHEMBL2496853 | 0.69 | RXFP1 (0.59) | PSMB8NPSR1RXFP1ADORA3ADORA1 | |
| SCHEMBL1278798 | 0.66 | GABRA5 (0.55) | ADORA3ADORA1CYP1A2KMT2ADAO | |
| SCHEMBL31093975 | 0.66 | GABRA5 (0.55) | ADORA3ADORA1CYP1A2KMT2ADAO | |
| SCHEMBL259052 | 0.65 | PSMB8 (1.00) | PSMB8NPSR1RXFP1MEN1KMT2A | |
| SCHEMBL11736118 | 0.62 | CDK4 (0.60) | ADORA3ADORA1ADORA2AADORA2BMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0809635-B1 | ALPHA-SUBSTITUTED HYDRAZIDES HAVING CALPAIN INHIBITORY ACTIVITY | WARNER LAMBERT CO (US) | 2001-10-04 | — | — | EP | claimed |
| US-5679680-A | α-substituted hydrazides having calpain inhibitory activity | WARNER-LAMBERT COMPANY (US) | 1997-10-21 | — | — | US | claimed |
| EP-0809635-B1 | ALPHA-SUBSTITUTED HYDRAZIDES HAVING CALPAIN INHIBITORY ACTIVITY | WARNER LAMBERT CO (US) | 2001-10-04 | — | — | EP | disclosed |
| EP-0809635-A1 | ALPHA-SUBSTITUTED HYDRAZIDES HAVING CALPAIN INHIBITORY ACTIVITY | WARNER-LAMBERT COMPANY (US) | 1997-12-03 | — | — | EP | disclosed |
| US-5679680-A | α-substituted hydrazides having calpain inhibitory activity | WARNER-LAMBERT COMPANY (US) | 1997-10-21 | — | — | US | disclosed |
| WO-1996025403-A1 | α-SUBSTITUTED HYDRAZIDES HAVING CALPAIN INHIBITORY ACTIVITY | WARNER-LAMBERT COMPANY (US) | 1996-08-22 | — | — | WO | disclosed |