Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 2/20 | 0.45 |
| ▸ | PDE7B | Q9NP56 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | MPI | P34949 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | CDC25B | P30305 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7783672 | 0.88 | LMNA (0.43) | KMT2AL3MBTL1MEN1MPILMNA | |
| SCHEMBL30910102 | 0.78 | PDE7A (0.51) | PDE7APDE7BMAPK1KMT2AL3MBTL1 | |
| SCHEMBL3150851 | 0.78 | PDE7A (0.51) | PDE7APDE7BMAPK1KMT2AL3MBTL1 | |
| SCHEMBL7782330 | 0.78 | PSMB8 (0.47) | MAPK1KMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL699273 | 0.74 | LMNA (0.65) | PDE7APDE7BKMT2AL3MBTL1MEN1 | |
| SCHEMBL29367625 | 0.74 | LMNA (0.65) | PDE7APDE7BKMT2AL3MBTL1MEN1 | |
| SCHEMBL5667519 | 0.74 | TSHR (0.42) | PDE7APDE7BKMT2AL3MBTL1MEN1 | |
| SCHEMBL5361973 | 0.74 | TSHR (0.42) | PDE7APDE7BKMT2AL3MBTL1MEN1 | |
| SCHEMBL9436260 | 0.69 | ALDH1A1 (0.41) | PDE7APDE7BKMT2AL3MBTL1MEN1 | |
| SCHEMBL258865 | 0.67 | PDE7A (0.68) | PDE7APDE7BKMT2AL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0809635-B1 | ALPHA-SUBSTITUTED HYDRAZIDES HAVING CALPAIN INHIBITORY ACTIVITY | WARNER LAMBERT CO (US) | 2001-10-04 | — | — | EP | claimed |
| EP-0809635-A1 | ALPHA-SUBSTITUTED HYDRAZIDES HAVING CALPAIN INHIBITORY ACTIVITY | WARNER-LAMBERT COMPANY (US) | 1997-12-03 | — | — | EP | claimed |
| US-5679680-A | α-substituted hydrazides having calpain inhibitory activity | WARNER-LAMBERT COMPANY (US) | 1997-10-21 | — | — | US | claimed |
| WO-1996025403-A1 | α-SUBSTITUTED HYDRAZIDES HAVING CALPAIN INHIBITORY ACTIVITY | WARNER-LAMBERT COMPANY (US) | 1996-08-22 | — | — | WO | claimed |
| EP-0809635-B1 | ALPHA-SUBSTITUTED HYDRAZIDES HAVING CALPAIN INHIBITORY ACTIVITY | WARNER LAMBERT CO (US) | 2001-10-04 | — | — | EP | disclosed |
| EP-0809635-A1 | ALPHA-SUBSTITUTED HYDRAZIDES HAVING CALPAIN INHIBITORY ACTIVITY | WARNER-LAMBERT COMPANY (US) | 1997-12-03 | — | — | EP | disclosed |
| US-5679680-A | α-substituted hydrazides having calpain inhibitory activity | WARNER-LAMBERT COMPANY (US) | 1997-10-21 | — | — | US | disclosed |
| WO-1996025403-A1 | α-SUBSTITUTED HYDRAZIDES HAVING CALPAIN INHIBITORY ACTIVITY | WARNER-LAMBERT COMPANY (US) | 1996-08-22 | — | — | WO | disclosed |