Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 13/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.37 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6306458 | 0.89 | SCN9A (0.40) | L3MBTL1SCN9AATMKMT2ACACNA1C | |
| SCHEMBL4413239 | 0.84 | NOTUM (0.47) | L3MBTL1SCN9ANOTUMKMT2ANR1I3 | |
| SCHEMBL8633273 | 0.81 | L3MBTL1 (0.40) | L3MBTL1NOTUM | |
| SCHEMBL4420583 | 0.75 | CASP6 (0.40) | SCN9ANOTUMKMT2ANR1I3 | |
| SCHEMBL29481070 | 0.73 | GRM7 (0.55) | ATMKMT2A | |
| SCHEMBL5638613 | 0.73 | L3MBTL1 (0.49) | L3MBTL1SCN9AKMT2ANR1I3 | |
| SCHEMBL4421108 | 0.72 | PSEN1 (0.42) | SCN9A | |
| SCHEMBL4417737 | 0.72 | PSEN1 (0.42) | SCN9A | |
| SCHEMBL7795540 | 0.71 | L3MBTL1 (0.44) | L3MBTL1SCN9ANOTUMKMT2ANR1I3 | |
| SCHEMBL28668564 | 0.71 | NAMPT (0.51) | NOTUMATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0853614-B1 | SUBSTITUTED TETRALYLMETHYLEN-OXINDOLE ANALOGUES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN SPA (IT) | 2001-10-04 | — | — | EP | disclosed |
| US-6147073-A | IMPROVED BIOAVAILABILITY | PHARMACIA & UPJOHN S.P.A. (IT) | 2000-11-14 | — | — | US | disclosed |