Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CALCRLCHRM1CHRM2CHRM3F2RMAOAMAOBMAP2K1MAP2K2NTRK1NTRK2NTRK3OPRD1OPRK1OPRM1P2RY12PKLRSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASLC18A2SLC6A2SLC6A3TLR7TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8dacAdacBdacCfolAftsImrcAmrcBmrdApolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmB1rpmB2rpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmHrpmIrpmJrpmJ2rpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsR1rpsR2rpsSrpsTrpsUrpsZykgMykgO
The experimentally established mechanism targets of Racemethionine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.50 |
| ▸ | BHMT | Q93088 | 10/20 | 0.47 |
| ▸ | BHMT2 | Q9H2M3 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | NOS2 | P35228 | 3/20 | 0.44 |
| ▸ | NOS3 | P29474 | 2/20 | 0.44 |
| ▸ | NOS1 | P29475 | 2/20 | 0.44 |
| ▸ | GCLC | P48506 | 1/20 | 0.41 |
| ▸ | GRM8 | O00222 | 1/20 | 0.41 |
| ▸ | GRM6 | O15303 | 1/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.41 |
| ▸ | GSR | P00390 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.41 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.41 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.41 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methionine SCHEMBL7781670 | 1.00 | RNPEP (0.50) | RNPEPBHMTBHMT2PMP22NOS2 | |
| Methionine SCHEMBL7781673 | 1.00 | RNPEP (0.50) | RNPEPBHMTBHMT2PMP22NOS2 | |
| Racemethionine SCHEMBL7783585 | 1.00 | RNPEP (0.50) | RNPEPBHMTBHMT2PMP22NOS2 | |
| Racemethionine SCHEMBL291985 | 0.96 | BHMT (0.50) | RNPEPBHMTBHMT2PMP22NOS2 | |
| Methionine SCHEMBL291986 | 0.96 | BHMT (0.50) | RNPEPBHMTBHMT2PMP22NOS2 | |
| Racemethionine SCHEMBL23930380 | 0.96 | BHMT (0.50) | RNPEPBHMTBHMT2PMP22NOS2 | |
| Methionine SCHEMBL1764849 | 0.94 | BHMT (0.49) | RNPEPBHMTBHMT2PMP22NOS2 | |
| Methionine SCHEMBL9192308 | 0.94 | BHMT (0.49) | RNPEPBHMTBHMT2PMP22NOS2 | |
| Racemethionine SCHEMBL29172847 | 0.94 | BHMT (0.49) | RNPEPBHMTBHMT2PMP22NOS2 | |
| Racemethionine SCHEMBL8463168 | 0.94 | BHMT (0.49) | RNPEPBHMTBHMT2PMP22NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0844239-B1 | Method for producing homocystine | MITSUBISHI CHEM CORP (JP) | 2001-10-04 | — | — | EP | disclosed |
| US-5847205-A | Method for producing homocystine | MITSUBISHI CHEMICAL CORPORATION (JP) | 1998-12-08 | — | — | US | disclosed |
| EP-0844239-A1 | Method for producing homocystine | MITSUBISHI CHEMICAL CORPORATION (JP) | 1998-05-27 | — | — | EP | disclosed |