Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | JUN | P05412 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | VCP | P55072 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.38 |
| ▸ | TUBB | P07437 | 2/20 | 0.38 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.38 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.38 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.38 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8842926 | 1.00 | GAA (0.44) | GAATDP1JUNNFKB1POLB | |
| SCHEMBL8842889 | 0.85 | ALDH1A1 (0.47) | TDP1MAPTSMN1; SMN2ALDH1A1TUBB4A | |
| SCHEMBL7793570 | 0.85 | MAPT (0.51) | GAATDP1JUNNFKB1POLB | |
| SCHEMBL7784722 | 0.85 | ALDH1A1 (0.47) | TDP1MAPTSMN1; SMN2ALDH1A1TUBB4A | |
| SCHEMBL7784715 | 0.84 | HDAC1 (0.48) | TDP1POLBMAPTHTTSMN1; SMN2 | |
| SCHEMBL7784713 | 0.84 | HDAC1 (0.48) | TDP1POLBMAPTHTTSMN1; SMN2 | |
| SCHEMBL7790430 | 0.81 | POLB (0.53) | POLBMAPTKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL8842878 | 0.81 | POLB (0.53) | POLBMAPTKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL8842915 | 0.81 | SMPD1 (0.50) | KDM4ETUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL8842912 | 0.81 | SMPD1 (0.50) | KDM4ETUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0723969-B1 | Phosphonocarboxylic acid derivatives and their use in treating degenerative articular ailments | HOECHST AG (DE) | 2001-11-14 | — | — | EP | disclosed |
| US-5627173-A | Phosphonoacetic acid derivatives and their use for treating degenerative joint disorders | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-05-06 | — | — | US | disclosed |
| EP-0723969-A1 | Phosphonocarboxylic acid derivatives and their use in treating degenerative articular ailments | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-07-31 | — | — | EP | disclosed |