Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KLK7 | P49862 | 1/20 | 0.43 |
| ▸ | KLK14 | Q9P0G3 | 1/20 | 0.43 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | SNCA | P37840 | 1/20 | 0.42 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.42 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8842878 | 1.00 | POLB (0.53) | POLBHDAC1HDAC2HDAC8APP | |
| SCHEMBL7794807 | 0.87 | POLB (0.43) | POLBHDAC1HDAC2HDAC8APP | |
| SCHEMBL7793572 | 0.84 | ALDH1A1 (0.39) | ALDH1A1KDM4EHPGDSMN1; SMN2MEN1 | |
| SCHEMBL7784715 | 0.83 | HDAC1 (0.48) | POLBHDAC1HDAC2HDAC8ALDH1A1 | |
| SCHEMBL7784713 | 0.83 | HDAC1 (0.48) | POLBHDAC1HDAC2HDAC8ALDH1A1 | |
| SCHEMBL8842889 | 0.82 | ALDH1A1 (0.47) | APPALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL7784722 | 0.82 | ALDH1A1 (0.47) | APPALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL7793570 | 0.82 | MAPT (0.51) | POLBHDAC1HDAC2HDAC8APP | |
| SCHEMBL8842926 | 0.81 | GAA (0.44) | POLBALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL7784710 | 0.81 | GAA (0.44) | POLBALDH1A1KDM4EHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0723969-B1 | Phosphonocarboxylic acid derivatives and their use in treating degenerative articular ailments | HOECHST AG (DE) | 2001-11-14 | — | — | EP | disclosed |
| US-5627173-A | Phosphonoacetic acid derivatives and their use for treating degenerative joint disorders | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-05-06 | — | — | US | disclosed |
| EP-0723969-A1 | Phosphonocarboxylic acid derivatives and their use in treating degenerative articular ailments | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-07-31 | — | — | EP | disclosed |