Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.48 |
| ▸ | TUBB | P07437 | 1/20 | 0.48 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.48 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.48 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.48 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.48 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.48 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.48 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.48 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7784713 | 1.00 | HDAC1 (0.48) | HDAC1HDAC8HDAC6HDAC3TUBB4A | |
| SCHEMBL8842915 | 0.85 | SMPD1 (0.50) | HDAC1HDAC8HDAC6HDAC3TUBB4A | |
| SCHEMBL8842912 | 0.85 | SMPD1 (0.50) | HDAC1HDAC8HDAC6HDAC3TUBB4A | |
| SCHEMBL7784709 | 0.85 | TNFRSF1A (0.50) | HDAC1HDAC8HDAC6HDAC3TUBB4A | |
| SCHEMBL8842926 | 0.84 | GAA (0.44) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL7784710 | 0.84 | GAA (0.44) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL7790430 | 0.83 | POLB (0.53) | HDAC1HDAC8HDAC2MAPTSMN1; SMN2 | |
| SCHEMBL8842878 | 0.83 | POLB (0.53) | HDAC1HDAC8HDAC2MAPTSMN1; SMN2 | |
| SCHEMBL8842889 | 0.82 | ALDH1A1 (0.47) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL7784722 | 0.82 | ALDH1A1 (0.47) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0723969-B1 | Phosphonocarboxylic acid derivatives and their use in treating degenerative articular ailments | HOECHST AG (DE) | 2001-11-14 | — | — | EP | disclosed |
| US-5627173-A | Phosphonoacetic acid derivatives and their use for treating degenerative joint disorders | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-05-06 | — | — | US | disclosed |
| EP-0723969-A1 | Phosphonocarboxylic acid derivatives and their use in treating degenerative articular ailments | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-07-31 | — | — | EP | disclosed |