Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | GLO1 | Q04760 | 4/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.47 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.47 |
| ▸ | ABAT | P80404 | 1/20 | 0.47 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.46 |
| ▸ | STAT3 | P40763 | 2/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.46 |
| ▸ | RELA | Q04206 | 2/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7784722 | 0.90 | ALDH1A1 (0.47) | MAPTALDH1A1TDP1CYP1A2APP | |
| SCHEMBL8842889 | 0.90 | ALDH1A1 (0.47) | MAPTALDH1A1TDP1CYP1A2APP | |
| SCHEMBL8842877 | 0.86 | PTP4A3 (0.51) | MAPTABL1ALDH1A1HPGDTDP1 | |
| SCHEMBL7794250 | 0.86 | PTP4A3 (0.51) | MAPTABL1ALDH1A1HPGDTDP1 | |
| SCHEMBL8842926 | 0.85 | GAA (0.44) | MAPTALDH1A1HPGDTDP1CYP1A2 | |
| SCHEMBL7784710 | 0.85 | GAA (0.44) | MAPTALDH1A1HPGDTDP1CYP1A2 | |
| SCHEMBL7784713 | 0.82 | HDAC1 (0.48) | MAPTALDH1A1HPGDTDP1KMT2A | |
| SCHEMBL7790430 | 0.82 | POLB (0.53) | MAPTALDH1A1HPGDAPPKDM4E | |
| SCHEMBL7784715 | 0.82 | HDAC1 (0.48) | MAPTALDH1A1HPGDTDP1KMT2A | |
| SCHEMBL8842878 | 0.82 | POLB (0.53) | MAPTALDH1A1HPGDAPPKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0723969-B1 | Phosphonocarboxylic acid derivatives and their use in treating degenerative articular ailments | HOECHST AG (DE) | 2001-11-14 | — | — | EP | disclosed |
| US-5627173-A | Phosphonoacetic acid derivatives and their use for treating degenerative joint disorders | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-05-06 | — | — | US | disclosed |
| EP-0723969-A1 | Phosphonocarboxylic acid derivatives and their use in treating degenerative articular ailments | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-07-31 | — | — | EP | disclosed |