Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MT-CO2 | P00403 | 3/20 | 0.39 |
| ▸ | TOP1 | P11387 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 4/20 | 0.38 |
| ▸ | CA1 | P00915 | 3/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7784776 | 0.90 | CA2 (0.43) | CA2CA1AKR1C3MEN1KMT2A | |
| SCHEMBL7784872 | 0.90 | TBXA2R (0.39) | MT-CO2TOP1CA2CA1AKR1C3 | |
| SCHEMBL7804341 | 0.87 | CA2 (0.37) | MT-CO2TOP1CA2CA1MEN1 | |
| SCHEMBL7938680 | 0.86 | MT-CO2 (0.32) | MT-CO2TOP1 | |
| SCHEMBL7787570 | 0.83 | AKR1C3 (0.33) | AKR1C3LMNASMN1; SMN2 | |
| SCHEMBL7794482 | 0.81 | CA2 (0.38) | MT-CO2TOP1CA2CA1AKR1C3 | |
| SCHEMBL7800486 | 0.81 | CA2 (0.37) | CA2CA1AKR1C3MEN1KMT2A | |
| SCHEMBL6035717 | 0.81 | CA2 (0.54) | CA2CA1AKR1C3MEN1KMT2A | |
| SCHEMBL7932216 | 0.80 | AKR1C3 (0.31) | CA2CA1AKR1C3CA12 | |
| SCHEMBL6035985 | 0.80 | MAPT (0.49) | MT-CO2AKR1C3MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140062-A2 | TREATMENT OF ASTHMA WITH MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000040235-A2 | TREATMENT OF ASTHMA WITH MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2000-07-13 | — | — | WO | disclosed |