Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 4/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ACACA | Q13085 | 1/20 | 0.31 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | TDO2 | P48775 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
| ▸ | KRAS | P01116 | 1/20 | 0.30 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7785574 | 0.89 | ALDH1A1 (0.45) | LMNAALDH1A1GAAKMT2AMAPT | |
| SCHEMBL7785129 | 0.89 | ALDH1A1 (0.45) | LMNAALDH1A1GAAKMT2AMAPT | |
| SCHEMBL7787615 | 0.87 | MAPKAPK2 (0.33) | IDO1TDO2KRASSOS1 | |
| SCHEMBL7780766 | 0.86 | IDO1 (0.39) | LMNAALDH1A1GAAIDO1TDO2 | |
| SCHEMBL7780536 | 0.86 | IDO1 (0.39) | LMNAALDH1A1GAAIDO1TDO2 | |
| SCHEMBL7780335 | 0.86 | LMNA (0.47) | LMNAALDH1A1ACACBMEN1KMT2A | |
| SCHEMBL7785286 | 0.85 | LMNA (0.35) | LMNAALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL7785093 | 0.84 | CXCL12 (0.39) | LMNAALDH1A1ACACBMAPTSMN1; SMN2 | |
| SCHEMBL7785478 | 0.84 | ADRB2 (0.36) | ALDH1A1MEN1KMT2ACNR2 | |
| SCHEMBL7785223 | 0.84 | ADRB2 (0.36) | ALDH1A1MEN1KMT2ACNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | disclosed |
| CN-1287117-A | Cyclobutene derivatives, preparation method and therapeutic use thereof | SANKYO CO (JP) | 2001-03-14 | — | — | CN | disclosed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |