Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | TDO2 | P48775 | 2/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | HPGDS | O60760 | 1/20 | 0.34 |
| ▸ | ATP1A1 | P05023 | 1/20 | 0.34 |
| ▸ | ATP1B1 | P05026 | 1/20 | 0.34 |
| ▸ | ATP1A3 | P13637 | 1/20 | 0.34 |
| ▸ | ATP1B2 | P14415 | 1/20 | 0.34 |
| ▸ | ATP1A2 | P50993 | 1/20 | 0.34 |
| ▸ | ATP1B3 | P54709 | 1/20 | 0.34 |
| ▸ | FXYD2 | P54710 | 1/20 | 0.34 |
| ▸ | ATP1A4 | Q13733 | 1/20 | 0.34 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7780536 | 1.00 | IDO1 (0.39) | IDO1TDO2NR1I2TRPM8SLC6A2 | |
| SCHEMBL7787615 | 0.93 | MAPKAPK2 (0.33) | IDO1TDO2NR1I2TRPM8SLC6A2 | |
| SCHEMBL28746788 | 0.91 | SLC6A2 (0.41) | IDO1TDO2SLC6A2SLC6A4MTOR | |
| SCHEMBL7780426 | 0.91 | SLC6A2 (0.41) | IDO1TDO2SLC6A2SLC6A4MTOR | |
| SCHEMBL7785286 | 0.91 | LMNA (0.35) | IDO1TDO2NR1I2TRPM8SLC6A2 | |
| SCHEMBL7785478 | 0.89 | ADRB2 (0.36) | SLC6A2SLC6A4ALDH1A1 | |
| SCHEMBL7785223 | 0.89 | ADRB2 (0.36) | SLC6A2SLC6A4ALDH1A1 | |
| SCHEMBL7785680 | 0.89 | NPC1 (0.41) | MTORGPR139ALDH1A1LMNAGAA | |
| SCHEMBL7780579 | 0.88 | SIGMAR1 (0.42) | HPGDSALDH1A1LMNAGAAMAPKAPK2 | |
| SCHEMBL7784931 | 0.88 | SIGMAR1 (0.42) | HPGDSALDH1A1LMNAGAAMAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | disclosed |
| CN-1287117-A | Cyclobutene derivatives, preparation method and therapeutic use thereof | SANKYO CO (JP) | 2001-03-14 | — | — | CN | disclosed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |