Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 8/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7785061 | 0.91 | KMT2A (0.44) | ADRB3KMT2AMEN1POLBTDP1 | |
| SCHEMBL7785275 | 0.89 | ADRB3 (0.46) | ADRB3KMT2AMEN1POLBTDP1 | |
| SCHEMBL7784885 | 0.89 | KMT2A (0.43) | ADRB3KMT2AMEN1POLBTDP1 | |
| SCHEMBL7780087 | 0.85 | KMT2A (0.45) | KMT2AMEN1POLBTDP1ALDH1A1 | |
| SCHEMBL7789113 | 0.84 | KMT2A (0.44) | KMT2AMEN1POLBTDP1GAA | |
| SCHEMBL7784907 | 0.83 | SIGMAR1 (0.44) | KMT2AMEN1POLBTDP1SMN1; SMN2 | |
| SCHEMBL7787169 | 0.81 | ALDH1A1 (0.58) | KMT2AMEN1POLBGAAALDH1A1 | |
| SCHEMBL7785313 | 0.80 | GPR88 (0.49) | KMT2AMEN1POLBGAAKDM4E | |
| SCHEMBL7787621 | 0.80 | KMT2A (0.43) | ADRB3KMT2AMEN1POLBTDP1 | |
| SCHEMBL7780429 | 0.79 | TDP1 (0.42) | KMT2AMEN1POLBTDP1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | disclosed |
| CN-1287117-A | Cyclobutene derivatives, preparation method and therapeutic use thereof | SANKYO CO (JP) | 2001-03-14 | — | — | CN | disclosed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |