Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | MITF | O75030 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CNR1 | P21554 | 2/20 | 0.47 |
| ▸ | CNR2 | P34972 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | CASR | P41180 | 2/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7787446 | 0.89 | MAPT (0.52) | KMT2AMEN1MAPTSMN1; SMN2TP53 | |
| SCHEMBL7780743 | 0.88 | KMT2A (0.52) | KMT2AMEN1MAPTSMN1; SMN2TP53 | |
| SCHEMBL7785132 | 0.86 | SIGMAR1 (0.48) | KMT2AMEN1MAPTSMN1; SMN2TP53 | |
| SCHEMBL7785114 | 0.84 | SMN1; SMN2 (0.48) | KMT2AMEN1MAPTSMN1; SMN2TP53 | |
| SCHEMBL7787584 | 0.83 | MEN1 (0.49) | KMT2AMEN1MAPTSMN1; SMN2TP53 | |
| SCHEMBL27540196 | 0.81 | ACP3 (0.50) | KMT2AMEN1MAPTSMN1; SMN2TP53 | |
| SCHEMBL7785642 | 0.81 | ACP3 (0.50) | KMT2AMEN1MAPTSMN1; SMN2TP53 | |
| SCHEMBL7780342 | 0.80 | KMT2A (0.54) | KMT2AMEN1MAPTSMN1; SMN2TP53 | |
| SCHEMBL7789039 | 0.80 | KMT2A (0.46) | KMT2AMEN1MAPTSMN1; SMN2TP53 | |
| SCHEMBL7785217 | 0.78 | FAAH (0.51) | KMT2AMEN1MAPTSMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | disclosed |
| CN-1287117-A | Cyclobutene derivatives, preparation method and therapeutic use thereof | SANKYO CO (JP) | 2001-03-14 | — | — | CN | disclosed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |