Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | ACP3 | P15309 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7787446 | 0.90 | MAPT (0.52) | MEN1KMT2AMAPTSMN1; SMN2TP53 | |
| SCHEMBL7785114 | 0.88 | SMN1; SMN2 (0.48) | MEN1KMT2AMAPTSMN1; SMN2TP53 | |
| SCHEMBL7785650 | 0.83 | KMT2A (0.50) | MEN1KMT2AMAPTSMN1; SMN2TP53 | |
| SCHEMBL7780743 | 0.83 | KMT2A (0.52) | MEN1KMT2AMAPTSMN1; SMN2TP53 | |
| SCHEMBL7785233 | 0.82 | AOC3 (0.52) | MEN1KMT2AMAPTSMN1; SMN2ADRB3 | |
| SCHEMBL7785132 | 0.81 | SIGMAR1 (0.48) | MEN1KMT2AMAPTSMN1; SMN2TP53 | |
| SCHEMBL7787629 | 0.80 | MAPT (0.42) | MEN1KMT2AMAPTSMN1; SMN2TP53 | |
| SCHEMBL27540196 | 0.80 | ACP3 (0.50) | MEN1KMT2AMAPTSMN1; SMN2TP53 | |
| SCHEMBL7785642 | 0.80 | ACP3 (0.50) | MEN1KMT2AMAPTSMN1; SMN2TP53 | |
| SCHEMBL7785221 | 0.79 | ALDH1A1 (0.64) | MEN1KMT2AMAPTSMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | disclosed |
| CN-1287117-A | Cyclobutene derivatives, preparation method and therapeutic use thereof | SANKYO CO (JP) | 2001-03-14 | — | — | CN | disclosed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |