Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 7/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.40 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | EP300 | Q09472 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7791053 | 0.83 | TSHR (0.47) | TSHRESR1ESR2HSD17B10KDM4E | |
| SCHEMBL7791031 | 0.83 | DHODH (0.43) | LMNATSHRESR1ESR2HSD17B10 | |
| SCHEMBL20123231 | 0.81 | KDM4E (0.52) | LMNATSHRHSD17B10KDM4EHPGD | |
| SCHEMBL7786715 | 0.80 | MAPT (0.53) | LMNATSHRHSD17B10KDM4EHPGD | |
| SCHEMBL2470133 | 0.79 | LMNA (0.55) | LMNATSHRHSD17B10KDM4EHPGD | |
| SCHEMBL17240274 | 0.75 | MAPT (0.50) | LMNATSHRESR1ESR2HSD17B10 | |
| SCHEMBL7789713 | 0.73 | FTO (0.53) | LMNATSHRESR1ESR2KDM4E | |
| SCHEMBL3741758 | 0.72 | KDM4E (0.60) | LMNATSHRHSD17B10KDM4EHPGD | |
| SCHEMBL5551334 | 0.71 | PLK1 (0.48) | LMNATSHRHSD17B10KDM4EHPGD | |
| SCHEMBL1791233 | 0.71 | KDM4E (0.66) | LMNATSHRKDM4EHPGDNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0801750-B1 | NOVEL SUBSTITUTED PHENANTHROPYRANS | PPG IND OHIO INC (US) | 2001-11-07 | — | — | EP | disclosed |
| EP-0801750-A4 | NOVEL SUBSTITUTED PHENANTHROPYRANS | PPG INDUSTRIES INC (US) | 1997-12-10 | — | — | EP | disclosed |
| EP-0801750-A1 | NOVEL SUBSTITUTED PHENANTHROPYRANS | PPG INDUSTRIES, INC. (US) | 1997-10-22 | — | — | EP | disclosed |
| US-5514817-A | PHOTOCHROMIC | PPG INDUSTRIES, INC. (US) | 1996-05-07 | — | — | US | disclosed |
| WO-1996004576-A1 | NOVEL SUBSTITUTED PHENANTHROPYRANS | PPG INDUSTRIES, INC. (US) | 1996-02-15 | — | — | WO | disclosed |