Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.45 |
| ▸ | AKT1 | P31749 | 2/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | KRAS | P01116 | 1/20 | 0.33 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.32 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | PRKCG | P05129 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | PRKACA | P17612 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | AKT2 | P31751 | 1/20 | 0.32 |
| ▸ | FLT4 | P35916 | 1/20 | 0.32 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.32 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27553525 | 0.90 | PDPK1 (0.39) | MAPKAPK2KRASSOS1MAPK1RPS6KB1 | |
| SCHEMBL7784936 | 0.90 | PDPK1 (0.39) | MAPKAPK2KRASSOS1MAPK1RPS6KB1 | |
| SCHEMBL7785234 | 0.89 | MAPKAPK2 (0.34) | MAPKAPK2KRASSOS1MAPK1RPS6KB1 | |
| SCHEMBL7780509 | 0.89 | MAPKAPK2 (0.34) | MAPKAPK2KRASSOS1MAPK1RPS6KB1 | |
| SCHEMBL7785553 | 0.88 | LMNA (0.34) | MAPKAPK2KRASSOS1MAPK1RPS6KB1 | |
| SCHEMBL7780705 | 0.88 | LMNA (0.34) | MAPKAPK2KRASSOS1MAPK1RPS6KB1 | |
| SCHEMBL7785101 | 0.88 | ADRB2 (0.36) | MAPKAPK2AKT1KRASSOS1MAPK1 | |
| SCHEMBL7785301 | 0.84 | MAPKAPK2 (0.47) | MAPKAPK2AKT1MAPK1RPS6KB1ROCK1 | |
| SCHEMBL7780640 | 0.84 | ALDH1A1 (0.41) | KRASSOS1MAPTGAAALDH1A1 | |
| SCHEMBL7780432 | 0.84 | ALDH1A1 (0.41) | KRASSOS1MAPTGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | disclosed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |